Abstract : Salvia Officinalis (sage) is a plant which has been used since ancient times for its culinary and medicinal effects and the uses of antimicrobial agent to control plaque and oral disease has been advocated for a number of years. Different compounds have been delivered through mouth rinses or tooth pastes or by topical application. The purpose of this research is to find out and to compare between the anticariogenic properties of aqueous and alcoholic sage extract on the growth of causative cariogenic bacteria (salivary Lactobacilli). In the present study lactobacilli were isolated from saliva of twenty-five dental students (age range between 20-21 years). These bacteria were isolated, purified and diagnosed according to morphological characteristic, biochemical tests and Vitek 2 system. Lactobacillus casei, Lactobacillus plantarum, Lactobacillus salivarius, and Lactobacillus acidophilus were isolated from stimulated saliva of students under study. Agar diffusion technique showed that sage extracts (aqueous and alcoholic) were inhibited the growth of lactobacilli, and the diameter of inhibition zone increased as the concentration of sage extract increased, but the effect of aqueous extract was less than the effect of alcoholic extract. The minimum bactericidal concentrations of aqueous and alcoholic sage extract were 50%, 20% respectively. Alcoholic sage extract inhibits salivary lactobacilli higher than aqueous extract