Abstract : The relationship of emotion with relation to the physical health of an individual can play a role in promoting overall better cardiovascular and metabolic health. This study was conducted to identify the relationship of human emotions with cardiovascular and metabolic health. The study participants were voluntarily recruited in a sequential manner without regard to gender, ethnicity, geography, or occupation. Participants older than 18 years were asked to fill out a validated questionnaire on human emotions. The BMI, blood pressure and blood glucose of the participants were assessed. The Mann-Whitney U test was applied to determine the metabolic and cardiovascular health of individuals with positive and negative emotions. There was a clinically significant difference in blood pressure, BMI and blood glucose between participants with positive and negative emotions. Participants having negative emotions had increased blood pressure, BMI and blood glucose levels as compared to participants with positive emotions. Metabolic and cardiovascular health is significantly affected by negative emotions leading to hypertension, Obesity and Diabetes. Improvement of metabolic and cardiovascular health is dependent on the management of emotional detox and promoting positive emotional learning.