Abstract : Abstract: There are many drivers for the emergence of antimicrobial resistance among pathogens. Misuse of antibiotics constitutes a growing global public health concern. There are many reports of outbreaks caused by bacterial strains that have acquired several mechanisms of antimicrobial drug resistance. Objectives: This study tries to assess the general public’s knowledge and opinions regarding the use of antibiotics and bacterial resistance in a rural area of Minia, Egypt. Methods: All the participants had to be older than 16 years and had to participate in the survey voluntarily. A total of 386 participants answered the questionnaire, from March 2018 to June 2018. Results: Most of the participants (82%) received antibiotics treatment with a prescription. More than half of the respondents (68.7%) discontinue their therapy after the alleviation of symptoms. Half of the participants (50%) in this study repeated the same antibiotic after having the same symptoms. The major source of antibiotic prescription was from family and friends (65.8%). The most common reason for the administration of antibiotics was sore throat (67.4%). Most of the participants (75.1%) understood that the antibodies resistance is the resistance of bodies to antibiotics and so they will no longer work as well. Most of the participants (69.9%) showed high awareness and agreement towards giving fewer antibiotics to farm animals. Conclusion: Based on the results, the authors thought that the most c