Vol - 28, Issue - 10
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[This article belongs to Volume - 28, Issue - 10]
International Medical Journal
Journal ID : IMJ-23-10-2021-1016
Total View : 2
Title : The Effect of Endurance Muscular Exercises on Ameliorating the Progressive Course of Non-Alcoholic Steatohepatitis in Obese Rats

Abstract : Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease, encompasses simple steatosis, steatohepatitis, fibrosis and cirrhosis. This study aimed to clarify the ameliorating effect of exercise during and after the development of nonalcoholic steatohepatitis via adipokine secretion. 60 male albino rats were divided into group I (control), group II (HFD induced obesity), group III (HFD with simultaneous exercise). Chemerin and insulin resistance (IR) were assayed. The circulating chemerin together with IR were significantly increased in group II as compared to control one. Meanwhile, practicing exercise from the first day significantly decreased the circulating chemerin levels together with IR as confirmed by histopathological examinations. In conclusion; exercise ameliorated the altered adipokine release and IR as pathogenic drivers in experimentally induced NAFLD.
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