Abstract : <p><strong>Abstract</strong>— Depression is a disorder of mood resulting in the reduction of productivity, an increase of suicide risk, and decreasing quality of life. The pathogenesis of depression might be associated with interleukin 6 (IL-6) that increases among depressed patients. Serotonin selective reuptake inhibitors (SRRI) agents have been widely used for the treatment of depression, but no reference discussed the comparison of the level of IL-6 among patients who were treated with SSRI and non-SSRI. This study determines the difference in serum IL-6 level among depressed patients were treated with SSRI and non-SSRI antidepressants. A cross-sectional study among 79 (54 SSRI groups and 25 non-SSRI groups) participants who were diagnosed with depression, having the medication with an antidepressant for at least 1 month were performed. The subjects then asked for venous blood collection for the serum IL-6 level examination. The comparison of serum IL-6 level was analyzed using the Mann-Whitney U Test. Our results demonstrated that there are no significant differences in the demographic, clinical characteristics, and serum IL-6 level among SSRI compared to the non-SSRI group (p=0.605). in conclusion, there is no significant difference in serum IL-6 levels among SSRI-treated depression patients compared to the non-SSRI groups.</p>