Abstract : The risk factor for the musculoskeletal disorder related to handheld devices will be persisted gripping, repetitive movements of the wrist, thumb, and fingers. The purpose of the study was to assess the effect of using mobile hand-held devices on the musculoskeletal system among physiotherapists. Method: This study was a descriptive cross-sectional study. The study conducted on 70 physiotherapists from Jenin city and under-graduated students of physiotherapy at Arab American University Palestine (AAUP). Results: the mean of the impact of using hand held-devices on Upper back/neck/shoulder pain was (3.39837), the impact of using hand held-devices on Upper back/neck/shoulder pain was (2.27834), the impact of using hand held-devices on Elbows/Wrist/Hand pain was (3.4), and the impact of using hand held devices on Knees/Feet pain was (1.5). Conclusion: The study confirmed that using hand held- devices had a negative effect on the upper musculoskeletal activity but the low effect on lower limbs