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Vol - 29, Issue - 01
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[This article belongs to Volume - 29, Issue - 01]
International Medical Journal
Journal ID
:
IMJ-13-01-2022-1196
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404
Title
:
The Effectiveness of hidrolized VCO Creams to Wound Sized, Increase of The Granulation Tissue Thickness and Amount of Fibroblas at Dermal-Superficial Burn Wound Healing on Wistar Rats
Abstract
: Hidrolized Virgin coconut oil (hVCO) contains several consituent fatty acids such as lauric acid, capric, and caprylate as well as phytosterol and polyphenols which are useful in wound healing. Randomized post test only with parallel group design was used. Thirty Wistar rats were divided equally into six groups randomly and then induced a Dermal-Superficial burn wound. Two groups became the control group treated with a base cream terminated on the 6th and 12th days, 4 other groups were treated with 70% and 100% hVCO cream which was terminated on the 6th and 12th day. Macroscopic wound diameter, histopathological examination of granulation tissue thickness and number of fibroblasts was measured in each group. There are significant differences in the macroscopic diameter of burns with smallest burn size wound was found in 70% hVCO group lower than control at 6th days (p=0.003) and 12th days (p<0.001). There are significant differences of the granulation tissue thickness of burns with the highest granulation tissue thickness was found in 70% hVCO group lower than control at 6th days (p=0.014) and 12th days (p=0.013). There are significant differences in the number of fibroblast of burns with the highest number of fibroblast was found in 70% hVCO group higher than control at 12th days (p=0.032). The 70% hVCO cream is effective to increase the granulation tissue thickness and amount of fibroblas at Dermal-Superficial burn wound healing compared both the control and 100% hVCO cream.
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