Abstract : Diabetic retinopathy is a significant cause of blindness in Saudi Arabia and worldwide. One in five people in Saudi Arabia is suffering from diabetes mellitus. Obstructive sleep apnea and diabetes when co-exist aggravate each other with deleterious consequences. We aimed to assess the relationship between obstructive sleep apnea and diabetic retinopathy in Tabuk, Saudi Arabia. This is a sectional study conducted at the Diabetes Center in King Fahd Specialist Hospital, Tabuk City, Saudi Arabia during the period from August 2021 to February 2022. Two hundred and eight patients with type 2 diabetes were included. A structured questionnaire was used to collect socio-demographic and cardiovascular risk factors. Obstructive sleep apnea risk was assessed by the STOP-BANG questionnaire. The Statistical Package for Social Science was used for data analysis. There were 208 patients with type 2 diabetes, their age was 51.98±12.90 years; the body mass index was 32.28±9.38, the duration of diabetes was 10.97±10.70, the Stop-Bang score ranged from 1-7 (mean± SD, 4.37±1.61) and the HBa1C was 9.44±1.67. Obstructive sleep apnea was highly prevalent (84.6%) and diabetic retinopathy was evident in nearly half of the patients (48.1%). No significant statistical difference was evident between patients with and without retinopathy regarding obstructive sleep apnea risk (4.7±1.7 versus 3.9±1.4, 95% CI, -0.14-1.6, P-value, 0.093. Obstructive sleep apnea and diabetic retinopathy were highly prevalent. No significant statistical association was evident between obstructive sleep apnea risk and diabetic retinopathy. Further larger multi-center studies are needed.