Abstract : Musculoskeletal pain is a major problem among adults and workers at a higher rate these days. It may be severe enough to interfere with your day-to-day life. The purpose of the study to assess the effectiveness of phonophoresis among patients with musculoskeletal pain. A quasi-experimental design was conducted on 41 patients with musculoskeletal pain. Data were collected using a self-reported questionnaire with three parts: First part Demographic data, the second part was the characteristics of pain: location of pain, type of pain, pain frequency and pain severity by a Visual Analog Scale (VAS) and The third part was the ultrasound parameters selected by the physiotherapist. An independent t-test and ANOVA was used to determine the effectiveness of Phonophoresis on musculoskeletal pain between patients The research results showed that ultrasound phonophoresis had a positive influence on pain and function in patients with moderate to severe musculoskeletal pain. The treatment was continued for 6 consecutive sessions. However, the improvement was significantly greater in the first three sessions. The current study concluded that Ultrasound and Phonophoresis both are beneficial for reducing pain with patients who have musculoskeletal pain