Abstract : Cancer due to secondhand smoke has an economic impact on society. One important element of this economic impact is the indirect cost associated with premature death (ICPD) of cancer due to secondhand smoke in Indonesia. This study aimed to estimating the indirect cost associated with premature death (ICPD) of cancer due to secondhand smoke in Indonesia. Epidemiological study using prevalence based is conducted. Estimation of ICPD of cancer due to secondhand smoke in Indonesia was conducted by multiplying smoking attributable cancer mortality with life expectancy and the average income. Life expectancy of Indonesian was taken from the WHO data Life Tables year 2016, while the average income of Indonesian population per gender was retrieved from National Statistics Bureau 2018. Total indirect cost associated with premature death (ICPD) of cancer related to secondhand smoke was IDR 1,832 trillion. ICPD of cancer due to secondhand smoking on male (IDR 1,270 trillion) was greater than ICPD of cancer due to secondhand smoking on female (IDR 562,101 million). Estimation the burden of cancer related to secondhand smoke helps the government in determining health programs and to reduce the burden of cancer related to secondhand smoke in Indonesia