Abstract : Odontogenic keratocyst OKC is a benign cyst of odontogenic origin. It accounts about 10% of all odontogenic cysts. It is characterized by a high rate of cell proliferation; relapse and locally aggressive growth guiding the type of surgical treatment choice and, consequently, the prognosis.The aim of this study is to determine the recurrence rate of odontogenic keratocyst after enucleation with peripheral ostectomy. A cross sectional study was conducted from Feb. 2015 to Jan. 2020. The patients included in this study were12 (4 females and 8 males), aged from 22 to 38 years old. Ten lesions were in the mandible and two in the maxilla. The distribution of the lesions as follow: 8 in the posterior mandible region, 2 in the anterior mandible, and one for each anterior maxilla and posterior maxilla. The size of OKCs lesions ranged from 1*1.5cm to 3*4 cm. The follow up after the surgery with enucleation and peripheral ostectomy with surgical round bur was from 6 months to 4 years. From all of the 12 OKCs, only one cyst recurred which was sized 1.5*2 cm in the anterior mandible region. The recured lesion managed by curettage only with curette under general anesthesia. Peripheral ostectomy is less invasive procedure for management of OKSc in comparison with resection, and associated with lower recurrence rate when compared with other maneuvers such as enucleation with or without carnoy's solution or liquid nitrogen and mursupialization alone or followed with enucleation