Abstract : It has been found that adipose tissues are able to produce certain secreted protein called Meteorin- like (Metrnl) as a novel adipokine, homologous to the neurotrophin metrn It may be considered as a hormone present in the circulation and secreted by white adipose tissues and skeletal muscles. This study was a trial to evaluate the relationship between metrnl serum level and insulin resistance. Patients and Method The study included 120 individuals categorized into two groups Group1 that included 68 patients with type II Diabetes Mellitus (T2DM). The source of the sample was the patients who attended the Diabetic Center at one of the major hospital in Basrah City. The second group included 52 healthy individuals. Metrnl (pg/ml) and several biochemical parameters were estimated for all participants including fasting blood glucose (mg/dL); Insulin) mlU/L); hemoglobinA1 (%); Alanine aminotransferase; aspartate aminotransferase and lipid profiles; Result: s. Metrnl was significantly increased in T2DM patient (4853±2930), p >0.05 compared to healthy (568±208). In conclusion: This study confirmed the positive correlation between metrnl plasma level and T2DM. Accordingly, an increase in metrnl plasma level may be workable procedure in insulin sensitivity.