Abstract : Myogenic Temporomandibular disorder is considered a general condition with patients visiting dental clinics. Etiology due to malocclusion, mechanical trauma, psychological stress, and stroke parafunctional activity. The current study was aimed to evaluate the therapeutic effects of diode laser at 940 nm compared with pharmacotherapy. Forty patients were diagnosed with pain in Temporomandibular Joint region and limited mouth opening have divided into two groups: first group received six-session laser therapy(n=25) for two weeks and second group received Indomethacin, Diazepam, and Paracetamol- Orphenadrine citrate (n= 15) for two weeks. Pain Intensity and maximum painless mouth opening were measured. Collection of results were done pre-treatment, post-treatment, and followed for 6 months. The Data had statistically analyzed using Shapiro- Wilk's test and Quade test using SPSS Statistics V. 20. The significant difference was p< 0.05. The laser therapy showed better maximum painless mouth opening during 3 months with less recurring symptoms of disorder