Abstract : Fractures of the humerus shaft accounts for 5% to 8% of total fractures. Usually they have a high tendency of fracture healing. Despite that non-union is usually found with an incidence of up to 15%. It depends on the type and location of fracture. Most Commonly found in proximal humerus fractures. Alcohol abuse, Diabetes Mellitus, Smoking, Age, Compound Fracture, Unstable primary osteosynthesis, vascular injury, and infection are common factors for non-union to occur. This retrospective study aimed to describe our treatment technique for this entity and present the results of the patient treated for infected nonunion of the humerus with implants in situ. A 55 year of lady presented in outpatient department of our hospital with complaints of pain and swelling of left arm. She gave a history of being operated for humerus fracture after a Road Traffic Accident 3 years back elsewhere with plate and screw fixation. There was no open wound at the time of injury. No Co-Morbidities. On examination she had a liner 15 cm scar of previous surgery healed with primary intention, localized swelling and erythema was present over posterior aspect of distal third humerus. Local temperature was increase, tenderness present over the swelling and scar. Infection was subsided with use of antibiotics bead and intravenous and oral antibiotics, followed by revision surgery with fibular strut graft with open reduction and internal fixation with plating and iliac crest bone graft achieved excellent union and clinical outcome over period of time.