: This manuscript provides a narrative review of Pathogenesis and transmission of coronavirus disease 2019 (COVID 19), proposes guidelines for dental practitioners and elaborate the currently available treatment strategies to fight the COVID 19 pandemic. Presently, the pandemic of COVID-19 caused by the latest strain of severe acute is highly infectious and is one of the biggest challenges faced by mankind. The hallmark of the infection is rapid human to human transmission by contact, and guidelines to prevent the virus dissemination is need of the hour. An electronic search was performed using PubMed, Scopus databases, Web of science databases. The selected articles were reviewed and cross checked for additional publications. The Data were generated with the following keywords: Pandemics, COVID 19, Diagnostics pf COVID-19, Dental Clinics, Aerosols, Infection Control, Personal Protective Equipment, Treatment of COVID-19. Dentists are at higher risk of acquiring the infection due to close facial contact with patients during dental procedures. The droplets and aerosols generated during clinical procedures are the major source of transmission. Therefore, dental clinics should adhere to strict infection control protocols and emergency dental procedures with donning of protective personal equipment. Saliva can be used as a potential non-invasive tool for early screening. Various clinical trials are underway to restrict the deadly pandemic.