: Chronic alcohol exposure has altered the prognosis and diagnosis of alcoholic liver disease (ALD) by non-coding RNAs (ncRNAs), gene expression and regulating the protein in the hepatic disease process. Many studies have shown that ncRNAs are involved in various biological processes and the progression of diseases. Long non-coding RNAs (lncRNAs), micro-RNAs (miRNAs), and circular RNAs (circRNAs) are major groups in ncRNAs that attract attention. Recently, RNA sequencing technologies have improved with advanced knowledge of molecular regulation pathways of lncRNAs and miRNAs. The aberrant role of lncRNAs followed by hepatic disease progression and significant regulatory role in biological processes, like cellular growth, cell cycle, proliferation, apoptosis, transcriptional factor regulation, etc. Hepatic fibrosis is a flexible wound healing process followed by accumulation of extracellular matrix (ECM) formation. Similarly, up and downregulation of lncRNAs affect cellular integrity and ECM accumulation in the liver disease progression. In hepatic disease progression, most lncRNAs regulate the cellular hemostasis process and therapeutic targets as potential biomarkers in clinical practice. It is of great significance to acquire a full knowledge of the biological processes and regulation of molecular mechanisms underlying hepatic injuries to find and target specific and sensitive molecules for hepatic regeneration. Therefore, lncRNAs have attracted considerable interest in the hepatic regeneration of following alcoholic abuse. In this review, we focus on the predictive role of lncRNAs regulatory factors that induced hepatic growth and regeneration..