: Upper aerodigestive tract (UADT) cancers is the common cancer in the world and the seventh most common cause of death from cancer worldwide. Some studies showed that Human Papillomavirus (HPV), Epstein-Barr virus (EBV) and Helicobacter pylori (H. pylori) infection is related to upper aerodigestive tract cancers. The aim of the study is to estimate the premature mortality cost related to infection of HPV, EBV, and H. Pylori in ASEAN. This research was a descriptive study using UADT cancers incidence and mortality data extracted from GLOBOCAN 2020. Population attributable fraction of six UADT cancers were calculated by reviewing previous studies of the infection prevalence data of 10 countries in ASEAN and relative risks of UADT cancers along with the mortality data from GLOBOCAN 2020. The burden of cancers attributable to HPV, EBV and H. Pylori Infection in ASEAN were calculated in term of premature mortality cost. Premature mortality cost was calculated by multiplying HPV, EBV and H. Pylori infection-related cancer mortality, ASEAN life expectancy, and ASEAN average income. According to the PAF estimation, HPV is responsible for approximately 5% - 18% of UADT cancer, whereas EBV is responsible for approximately 15% - 91% of UADT cancer. Helicobacter Pylori HPV is responsible for between 16 and 69% of UADT cancer in ASEAN. The highest PMC for males is $516 million due to nasopharynx cancer caused by EBV infection in Indonesia, and the highest PMC for females is $300 million due to nasopharynx cancer caused by EBV infection in Indonesia. In ASEAN, nasopharyngeal cancer has the largest cost of premature mortality due to HPV, EBV, and H. Pylori. In terms of excess deaths, it imposes a significant economic burden. The burden of UADT can be reduced by intervention in lifestyle, education in health care and policies..