International Medical Journal

I analyze the sexography of Wardell Pomeroy (1913-2001), a junior collaborator of Alfred Kinsey in case history collection and the 2nd author of the two landmark volumes of 'Human Sexual Behavior published in 1948 and 1953 respectively. Pomeroy's oeuvre (books, book chapters and journal articles) was studied. Pomeroy was a clinical psychologist with a PhD from Columbia University in 1954. A total of 31 items, published between 1948 and 1990 included 9 books, 7 book chapters, 1 foreword to a book on tattoos, and 14 journal articles of miscellaneous variety. As such, Pomeroy's published productivity was quantitatively less in comparison to that of his junior contemporary physician sexologists William Masters and Alex Comfort. As Pomeroy published only 27 items (including 4 sole-authored books) during his post-Kinsey period, his reputation as a sexuality scholar remains firmly linked with the two Kinsey reports, in which he was the 2nd author. But this hardly dents Pomeroy's impeccable reputation as a pioneering sexologist of mid-20th century.

Dental anomalies are the formative defects that occur as a result of multifactorial interactions between genetic or environmental factors during the process of tooth development. Literature has revealed presence of multiple dental anomalies such as supernumerary tooth, tooth agenesis, ectopic tooth eruption, atypical tooth size or shape, taurodontism, pulp stones etc in various syndromic or non-syndromic conditions. Although asymptomatic, but early diagnosis is requisite for better patient management to prevent the occurrence of associated complications. Here, we report a rare case of 23-year-old male patient who presented with cardiovascular manifestations along with multiple dental and skeletal findings. Such combination of dental and skeletal findings has not been reported earlier in association with any individual syndrome. Hence, we propose it to be a new syndrome of non-genetic type associated with multiple cardiac, skeletal and dental anomalies.

The present study aims to evaluate the relevance of IFNλ4rs73555604 SNP and ERAP1rs26618 SNPs and response to direct anti-viral drugs among HCV infected Egyptian patients. 100 participants were included in the study (40 HCV infected patients responded to DAA therapy, 40 HCV infected patients who did not respond to DAA and 20 healthy volunteers). Allelic discriminations of IFNλ-4 rs73555604SNP and ERAPrs26618SNP were carried out using step One real-time PCR. Allelic discrimination of IFNλ4rs73555604 and ERAP1rs26618 exhibited significant differences among the studied groups where 75% of non-responders carry IFNλ4rs73555604T allele while 75% of responders carry ERAPrs26618C allele. Calculations of odds ratio revealed that persons carrying T allele of INFλ4rs555604 and ERAPrs26618 have 2.5 and 3.3 folds more odd to be non-responder to DAA therapy, respectively. IFN-λ-4rs73555604 and ERAP-1rs26618 polymorphism could affect HCV response to DAA treatment among HCV infected Egyptian patients. There was a significant association between INFλ4rs555604CC genotype and response to treatment. However, ERAP1rs26618T-allele was associated with resistance to treatment. Odds ratio calculation revealed that persons carrying ERAPrs26618T allele have 3.3 folds more odd to be non-responder to DAA therapy. Both SNP can be used as surrogate markers to assess response to DAA treatment.

The present paper aimed at discussing the advances of pharmacological treatment of COVID-19 and highlighting the recent findings reported by either international medical bodies or specialized pharmacological research groups. The study adopted the narrative review approach through exploring and analyzing the findings reported in literature during the period of COVID-19 pandemic, in addition to providing commentary notes regarding the released statements of pharmacological research groups. The findings of the study revealed that there is a significant advancement in COVID-19 therapy. However, still there is a significant lack of a single research-based evidence that the released or suggested drugs are effectively eradicating the COVID-19 viral infection. The study concluded that commitment to the announced precautionary measures at the meantime remains the most appropriate action to be taken until a reliable research-based evidence is released regarding the effectiveness of the pharmacological treatments of COVID-19 infection.

A common technique employed in medical research is to answer questions using statistical inference and to calculate an appropriate test statistic and confidence interval that will determine whether some hypothesis should be rejected or otherwise. There are many issues to consider, including the controversial matter of whether a one- or two-sided alternative is appropriate. The objective of this paper is to provide a precise interpretation of a confidence interval as well examining how conditional probability should be interpreted. A novel approach is undertaken for explaining the p-value in relation to a confidence interval that has been used to test a medical hypothesis. It is also apparent that even skilled medical researchers have not been sufficiently trained in statistical analysis do not have the ability to interpret statistical results. Examples to illustrate the techniques are provided. The results in this paper will enable the medial researcher to better understand the nature of confidence intervals and to use them more effectively in reaching conclusions. It is known that there are a number of medical research articles appearing in refereed journals that contain erroneous conclusions through the misinterpretation of data analysis. This paper uses a case study to illustrate that their findings can often be misleading or just plain wrong.