: A major component of radiology practice is communication. Within a radiographic examination, it is important for the radiographer to communicate successfully with the patient so as to be considered trustworthy and reliable by the latter. The radiographer must possess effective communication skills, especially when dealing with difficult patients. The purpose of the present work is to explore how effective and how frequent various patient-radiographer communication obstacles are. Convenience sampling was applied to recruit 150 patients and 32 radiographers to undertake a descriptive qualitative cross-sectional study at King Khalid Hospital in Najran, Saudi Arabia, in the period July 2018-November 2019. Two questionnaires respectively intended for patients and radiographers were the tools employed for data collection. From the radiographers’ perspective, language and religious differences were the obstacles of greatest and least significance (mean 1.94±0.66 and mean of 1.40±0.47, respectively). From the patients' perspective, the main communication obstacle was gender differences (mean 2.06±0.31), while the most insignificant communication obstacle was physical condition (mean 1.63±0.75). The radiographers' perspectives did not differ significantly from the patients’ perspectives (P≥0.05). Regarding the preferred language for the radiographic examination, Arabic was preferred by a proportion of 44.7% of participants, while English was preferred by 39.3%. This study found that gender and language differences were the main obstacles to communication between patients and radiographers. The radiographers involved in this research demonstrated professionalism and decency in their interaction with the patients. It is suggested that radiographers should be provided with proper training for communication skills to ensure that they can efficiently interact with patients, particularly those from a cultural background different from their own. It is necessary to develop better training programs and courses taking into account the cultural and linguistic particularities of Saudi Arabia.