: Inappropriate use of medications during pregnancy may result in some functional and structural side effects on the development of the child. This study was set to ascertain the prevalence of self-medication practice and associated factors among pregnant women in Baghdad city. A cross-sectional survey was carried out among 550 pregnant during the period from January through June 2019. The sample was collected from 20 primary health care centers (ten in each side of Baghdad). Out of 550 pregnant, 48.6% reported practicing self-medication (medical and herbal), predominantly among the age group (20-29 years) and mainly in those with primary and secondary education (47.8%, 49.2%). The main precipitating factors were previous experiences (37.2%), easy access from pharmacies (33.8%), and to save89 doctor’s fees (25.6%). There was a significant relation between self-medication and age, parity and stage of pregnancy. Although 48% believe that it is harmful to the fetus; 28.9% of the participants expressed an intention to practice self-medication in the next pregnancy. Self-medication in Iraq is an important health problem considering its relatively high prevalence. Easy access to a wide range of medicines without prescription is the main factor responsible for this irrational use.