International Medical Journal

Journal ID : IMJ-12-08-2021-881

Total View : 425

Title : THE ASSOCIATION BETWEEN VERTEBROBASILAR INSUFFICIENCY AND MIXED DEMENTIA IN GERIATRIC POPULATION

Abstract : Vertebrobasilar insufficiency (VBI) mainly affects elderly people and involves reduced blood flow in the posterior part of the brain. The vertebrobasilar (VB) flow system is also called the posterior circulation, comprising the vertebral arteries, basilar artery, and posterior cerebral arteries and their branches, supplying the brainstem, thalamus, hippocampus, cerebellum, and regions of the occipital and temporal lobes. Dementia is the outcome of the Vertebrobasilar insufficiency that can be proved as lethal source for life. In this affected person loose the senses of maturity, reasoning for life and whatever is happening in the state of livings. To determine the association between vertebrobasilar insufficiency and mixed dementia in geriatric population. Analytical cross sectional study was conducted to determine association between vertebrobasilar insufficiency and mixed dementia. Sample of 135 elderly people was taken from different Neuro- centres in Lahore. VBI test of the participants was done. Mini-Mental State Examination of dementia Levels was evaluated. 23% were having positive VBI test. 77% were negative. 51.9% were having mild dementia, 25.9% were having moderate dementia, 14.1% were having no dementia and 8.1% were having severe dementia. Mean MINI-MENTAL STATE EXAMINATION Score was found 21 out of total 30 with SD±5.4. Higher score indicates lower dementia. P value indicates that there is significant association between VBI test and MINI-MENTAL STATE EXAMINATION (P value .000) This study concluded that there is significant association between VBI test and MINI-MENTAL STATE EXAMINATION..
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International Medical Journal

Journal ID : IMJ-10-08-2021-879

Total View : 9

Title : Effectiveness of lifestyle modification intervention programme on quality of life, bone health status, physical function capacity and medication adherence among postmenopausal women with osteoporosis: A mixed method study protocol

Abstract :

Osteoporosis is the major problem worldwide. Though it affects both the gender, women are the most commonly affecting group due to their physiological differences. This study protocol is designed to evaluate the effect of lifestyle modification intervention programme on quality of life, bone health status, physical function capacity and medication adherence among postmenopausal women with osteoporosis. A mixed Method approach adopting a Sequential explanatory design is proposed for this study. The study will be carried out in two phases. The randomized control trial in the phase 1 includes postmenopausal women of age group 45-65 years with the Bone mineral density scores between -1 and -3. The participants are further categorized into experimental and control group. The experimental group will receive interventions on lifestyle modifications whereas control group will continue with the standard care. Quality of life is the primary outcome measure and bone mineral density; physical functional capacity and the medication adherence are the secondary outcome measures. Follow up is done at 3 months and 6 months followed by that qualitative data from the sub-sample of the main sample related to the experiences living with osteoporosis while undergoing the Lifestyle Modification Intervention Program will be collected in phase 2. If the lifestyle modification in this study shows positive outcomes, it may be amalgamated in standard patient care. Since pharmacological therapies often have the risk of side effects and are expensive, more complications can be avoided if patients adopt lifestyle changes as their way of life.

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International Medical Journal

Journal ID : IMJ-10-08-2021-875

Total View : 458

Title : EVALUATION OF SERUM INTERLEUKIN 1 BETA AND INTERLEUKIN 6 IN ORAL SUBMUCOUS FIBROSIS – A CROSS-SECTIONAL STUDY

Abstract : Oral submucous fibrosis [OSMF] is a potentially malignant disorder of oral cavity. The epidemiology of OSMF strongly suggests an individual susceptibility which could be cytokine based, especially as the initial feature of OSMF is chronic inflammation accompanied by chronic fibrosis. Cytokines can act as Prognostic tools for detecting malignant transformation of oral potentially malignant disorders. It has been evident that different cytokines are expressed by dysplastic cells, the most common of which include tumour necrosis factor alpha [TNF-α], IL-1, IL-6, and IL-8. To assess the Serum levels of IL- 1 beta, and IL-6 in oral submucous fibrosis patients. This study group comprised 75 individuals divided into 3 groups GROUP A with 25 and GROUP B with 25 OSMF individuals, GROUP C 25 healthy individuals as controls. Serum levels of IL-1β, IL-6 were measured using enzyme linked immunoassay kits in all the subjects. The present study showed a significant rise in serum levels of IL-1beta and IL-6 levels in OSMF patients in contrast to the control group with the significance of p-value [<0.05]. Proinflammatory cytokines IL-1β and IL-6 were elevated, might act as a diagnostic and prognostic marker in oral submucous fibrosis patients..
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International Medical Journal

Journal ID : IMJ-10-08-2021-874

Total View : 363

Title : ASSESSMENT OF CLINICO – HISTOLOGICAL REGRESSION AND EXPRESSION OF COX-2 ENZYME LEVELS IN PATIENTS WITH ORAL LEUKOPLAKIA POST TREATMENT WITH FREEZE-DRIED BLACK RASPBERRY CAPSULES: A RANDOMIZED CLINICAL TRIAL

Abstract : Oral leukoplakia - most common potentially malignant disorder and its management is currently not evidence-based. The present study intends to determine the efficacy of freeze dried black raspberry capsules on clinical and histopathological retro gradation and also regression of COX – 2 enzyme levels in patients with oral leukoplakia. A total of 30 patients diagnosed with oral leukoplakia were randomly divided into 2 groups – group A and group B. A detailed clinical examination was done and size of the lesion was noted. For both groups punch biopsy was done and blood sample was collected before the start of treatment and after 45 days. Group A were treated with 300mg freeze dried black raspberry capsules twice daily for 45 days and group B was treated with antioxidant capsules (SM Fibro) twice daily for 45 days. To test the mean difference between the two groups, a student’s t-test (paired sample t-test & independent sample t-test) was used. Statistically, a significant difference was not found in both groups regarding the size of the lesion (P > 0.005). However, the study demonstrated a statistically significant decrease in COX-2 enzyme levels in group A than in group B (p < 0.005). Half of the patients in both the groups should one unit of improvement histologically which is not statistically significant. Based on the study outcome, it was concluded that management of oral Leukoplakia with dietary supplementation of black raspberry capsules can be considered one of the treatment modalities..
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International Medical Journal

Journal ID : IMJ-09-08-2021-873

Total View : 499

Title : Effects of Covid-19 on private dental practice

Abstract : The covid-19 pandemic is a major public health crisis globally and has affected the practice of medicine and dentistry. The objective is to compare the effects of immediate pre-covid-19 period and the covid-19 period in our private dental practice. This was a retrospective study conducted at pre-covid-19 pandemic (January-December, 2019) and during covid-19 pandemic (January-December, 2020) in a private dental clinic in Najran, Kingdom of Saudi Arabia. Our dental clinic runs services based on three Departments (Clinical, Administrative and Research). Patients demographics and turnout with new and follow-up cases were recorded during both periods. Total number of new patients during the pre-covid-19 (2019) era was 2,271 while during the covid-19 (2020) era was 2,535. In terms of patients visit to the center, 18,176 patients visited the dental clinic in 2019, while 19,842 visited in 2020. Regarding dental services rendered, 9,596 services were rendered in 2019 while 16,039 were rendered in 2020. It was observed from this study that there was a sharp drop in patients visit to our clinics because of the total lockdown put in place by the government. This, however improved during the partial ease of lockdown..
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Submission Deadline ( Vol 30 , Issue 04 )
20 Apr 2023

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Publish On ( Vol 30 , Issue 03 )
31 Mar 2023