: Irritable Bowel Disease and diabetes are common in pregnancy. This systematic review aims to identify drugs that can be safely used in this condition to control the disease and induce remission while not causing harm to the fetus. This review will also provide updates and serve as a guide for safe prescribing of such treatments. A total number of 20 articles that met the study criteria were chosen and analyzed using PRISMA guidelines. GRACE guidelines were used for quality assessment. Primary database; PubMed, clinical key, google scholar were used for data search. Certain drugs used in IBD are strongly associated with incidence of birth defects as well as poor pregnancy outcomes. Few data on the use of other antidiabetic in pregnancy apart from metformin, glyburide insulin was found. Though a few were associated with an increased incidence of IBD in diabetes. This study focuses on drugs belonging to FDA categories B and C. The findings indicate that Insulin, Glyburide and metformin are safe for use in pregnancy, ASA, Biologics and immunomodulators are considered safe for use in pregnancy. Disease control prior to conception is also necessary to prevent complications and improve pregnancy outcomes.