International Medical Journal (ISSN:13412051)

Aim and Scope

Aim-

International Medical Journal ISSN: (13412051) is an international open-access journal publishes twelve times each year. The "International Medical Journal" is a peer-reviewed, monthly, online international research journal, which publishes original articles, research articles, review articles with top-level work from all areas of Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody, ENT etc. Researchers in all Medical Science and Pharmacy fields are encouraged to contribute articles based on recent research. Journal publishes research articles and reviews within the whole field of Medical Science and Pharmacy Research, and it will continue to provide information on the latest trends and developments in this ever-expanding subject. International Medical Journal journal covers almost all disciplines of Medical Science and Pharmacy. Researchers and students of M.B.B.S, M.D., D.T.C.D., GYNE., M.S., M.Pharma, And PhD are requested to send their original research articles to International Medical Journal.

Scope-

International Medical Journal ISSN: (13412051) is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:

Anatomy Physiology Biochemistry Pharmacology
Pathology Forensic medicine Microbiology Community Medicine
Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology
Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases
Anaesthesia Cancer research Neurosurgery Orthopedics

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Latest Journals
International Medical Journal
Journal ID : IMJ-10-01-2020-134
Total View : 490
Title : Phytochemical Analysis and Anticancer Evaluation of Iraqi Herb Chenopodium Murale Extracted by Microwave-assisted Extraction
Abstract : Chenopodium murale is a medicinal herb with biological functions that has been studied with common extraction methods. However, studies on Iraqi C. murale (ICM) have not yet been reported. Microwave-assisted extraction (MAE) was used as a green extraction method for the first time with C. murale. The phytochemical components were profiled by GC-MS, which showed about 11 compounds. The highest peak occurred for compound 6 (phytol, acetate), followed by compounds 9 and 10, which belong to the same compound (hepatocosane). The ethanol extract displayed antioxidant action with IC50 = 102.3 µg/ml, which was compared to vitamin C as a positive control (IC50= 79.69 µg/ml). We tested the toxicity of ICM against two types of cancer cell lines, breast cancer (MCF-7) and liver cancer (HACM), for which the IC50 values were estimated as 1504 and 1267 µg/ml, respectively. Late apoptosis values were 73.4 and 58.5 for MCF-7 and HCAM, respectively, and cell cycle arrest occurred in the G1 phase for HCAM and the G2 phase for MCF-7. The results were compared with control cells. In vitro, normal kidney cells showed limited toxicity from the extract, which was compared with highly toxic doxorubicin as a positive control. The results suggest that the MAE method for ICM produced selective bioactive compounds, which may behave as potential natural anti-breast and anti-liver cancer agents. The results could help in the development of future investigations with regular doses to prevent liver and breast cancer.
Full article
International Medical Journal
Journal ID : IMJ-10-01-2020-133
Total View : 379
Title : OPTIMIZATION OF NANOEMULSION GEL FORMULATION OF MANGROVE LEAF EXTRACT (Acanthus Illicifolius)
Abstract : Mangrove leaf is one of the plants that grow in the waters of the island of Java that has potential as a medical plant. There have been many people living around the cultivation of mangrove leaves who have used mangrove leaves as a medicine that is to treat pain. One type of mangrove species that has potential as a medicinal plant is the Acanthus illicifolius mangrove. However, the use of mangrove leaves for treatment has not yet found as an easy and practical dosage form. People only use it by pounding it and affixing it to the sick part. This study aims to determine the nanoemulsion gel formulation of mangrove leaf extracts with a comparison of Na CMC concentrations so that easily used by the public. This research is an experimental study comparing the concentration of the gelling agent as the basis for making nanoemulsion gels. This study used three formulations of nanoemulsion gel preparations namely Na CMC 3%, Na CMC 4%, and Na CMC 5%. The results of this study are seen from the organoleptic test that nanoemulsion gel using 3% Na CMC produced a too runny preparation and 5% Na CMC preparations that were produced were too thick so that resulting preparation could not be tested for the physical properties of the preparations. For preparations that use 4%, Na CMC produce is good manufacturing product of nanoemulsion gel, so that it’s proceeded to the stages of testing the physical properties of nanoemulsion gel preparations.
Full article
International Medical Journal
Journal ID : IMJ-08-01-2020-130
Total View : 489
Title : Relationship between TOP2A mRNA Expression with Neoadjuvant Chemotherapeutic Response in Breast Cancer
Abstract : Anthracycline is commonly used in neoadjuvant chemotherapy for breast cancer, although not all patients benefit from the therapy. Studies suggest that expression of TOP2A associated with Anthracycline sensitivity. Purpose: To know the relationship between the profile of baseline TOP2A mRNA expression and chemotherapy response in locally advanced breast cancer. An observational study, thirty breast cancer tissue samples pre-chemotherapy treated using cyclophosphamide-doxorubicin-5fluorouracyl regiment. Detection of TOP2A mRNA expression using qRT-PCR techniques. Clinical response to neoadjuvant chemotherapy based on RECIST criteria. The mean value of TOP2A mRNA expression in breast cancer patient’s prechemotherapy was 9.753±2.755, range 4.470–13.810. The mean value of TOP2A mRNA expression in breast cancer patients which responsive to chemotherapy was 10.601±2.208. The mean value of TOP2A mRNA expression in breast cancer patients, which nonresponsive to chemotherapy, was 6.969±2.648. Mean difference was 3.632, significant with p-value =0.001(p<0.05). There is a positive correlation between TOP2A mRNA expression with the clinical response with a value of r =0.475; this correlation was significant with p-value=0.004 (p<0.05). This study found a correlation between the profile of baseline TOP2A mRNA expression with clinical response to neoadjuvant chemotherapy in breast cancer.
Full article
International Medical Journal
Journal ID : IMJ-08-01-2020-129
Total View : 135
Title : Prevalence of Anemia Types Among Overweight and Obese Patients Attending The Obesity Research and Therapy Unit at AL-Kindy College of Medicine.
Abstract : Anemia is considered by World Health Organization as a global health problem. It can be affected by the body mass index of an individual since increasing weight can result in low-grade systemic inflammation and elevation of hepcidin which results in sequestration of iron inside a variety of cells including macrophages, hepatocytes and enterocytes and this would lead to the development of what is known as anemia of inflammation. To evaluate the effects of body mass index on complete blood count parameters. In this cross-sectional study, the data of 200 overweight and obese patients with complete blood count, for all ages were collected. They were grouped according to body mass index into overweight and obese; different complete blood count parameters were noted. Intergroup comparison was applied regarding different blood parameters and the relations with body mass index were calculated. The prevalence of anemia was 26%. For anemic cases 71.2% are females and the residual are males. There were effects of increasing body mass index on complete blood count parameters.
Full article
International Medical Journal
Journal ID : IMJ-08-01-2020-128
Total View : 432
Title : Socioeconomic Disparities of Facility-Based Childbirth in Indonesia
Abstract :

In Indonesia, only 74% of women give birth in health care facilities. This study was conducted to analyze the socioeconomic disparities of facilities-based childbirth in Indonesia. The analysis in this study uses raw data from the 2017 Indonesia Demographic and Health Survey (IDHS). With stratification and multistage random sampling, 17,769 women aged 15-49 years with live births in the last 5 years were sampled. Data were analyzed using a Binary Logistic Regression test. Poorer women were 1.898 times more likely to use healthcare facilities for delivery than poorest women. Middle women were 2.669 times more likely to use healthcare facilities for delivery than poorest women. Richer women have 3.163 times more opportunities to use healthcare facilities for delivery than poorest women. The richest women were 6.566 times more likely to use healthcare facilities for delivery than the poorest women. Women who live in urban areas were 2.412 times more likely to use healthcare facilities for delivery than those who live in rural areas. Age, parity, level of education, ownership of health insurance, knowledge of the danger signs of pregnancy, and antenatal care, in maternity women the past five years significantly contribute to the utilization of healthcare facilities for delivery. There was a significant disparity between socioeconomic in utilizing healthcare facilities for delivery in Indonesia. Women with better socioeconomic status have better possibilities for utilizing healthcare facilities for delivery

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