International Medical Journal (ISSN:13412051)

Aim and Scope

Aim-

International Medical Journal ISSN: (13412051) is an international open-access journal publishes twelve times each year. The "International Medical Journal" is a peer-reviewed, monthly, online international research journal, which publishes original articles, research articles, review articles with top-level work from all areas of Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody, ENT etc. Researchers in all Medical Science and Pharmacy fields are encouraged to contribute articles based on recent research. Journal publishes research articles and reviews within the whole field of Medical Science and Pharmacy Research, and it will continue to provide information on the latest trends and developments in this ever-expanding subject. International Medical Journal journal covers almost all disciplines of Medical Science and Pharmacy. Researchers and students of M.B.B.S, M.D., D.T.C.D., GYNE., M.S., M.Pharma, And PhD are requested to send their original research articles to International Medical Journal.

Scope-

International Medical Journal ISSN: (13412051) is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:

Anatomy Physiology Biochemistry Pharmacology
Pathology Forensic medicine Microbiology Community Medicine
Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology
Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases
Anaesthesia Cancer research Neurosurgery Orthopedics

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Latest Journals
International Medical Journal
Journal ID : IMJ-23-08-2023-1634
Total View : 469
Title : Computational study for predicting the effects of missense variants on PTEN protein : assessement of functional and structural impact and association with prostate cancer
Abstract : Studies on nsSNPs have demonstrated their implications in several pathologies including hereditary diseases. In cancerous diseases, several genes have been the subject of studies in search of a possible contribution, particularly in hereditary cancers such as prostate cancer. The PTEN gene is one of the candidates frequently studied in this cancer, primarily due to its crucial role in the PIK3/AKT pathway, which is one of the fundamentals signaling pathways involved in carcinogenesis. Throughout this study we employed various computational approaches to identify nsSNPs that maybe deleterious to the structure and/or function of PTEN protein and potentially contributing to diseases such as cancers. The analysis was performed by executing various valid computational tools, including : SIFT, PANTHER, ALIGN GVGD, PolyPhen.2, I.Mutant.2, Fathmm, ConSurf, Interproscan, Raptor X, SWISS-MODEL. Out of 573 variants, 148 variants were found to be deleterious after analysis by the four tools (SIFT, Polypehen2, Panther, Align GVGD). Further evaluation of these variants by the three tools consurf, Fathmm and I.Mutant allowed the identification of 97 SNPs associated with cancer and decrease the stability of the protein. Analysis of the functional domains of the protein (InterProscan tool) revealed that 86% of the variants are located in the PTP domain, of which 14 variants correspond to 7 codons situated in the active site of the protein. Protein structure property prediction by Raptor X server showed significant differences in secondary structure (SS), solvent accessibility (ACC), and disorder regions (DISO). The results of this study support the probability of a pathogenic effect of the 14 variants of the PTEN protein : I122S, H123D, C124S, C124R, C124G, C124Y, G127R , G127V, G129R, G129V, R130G, R130P, G132D, G132V. With the emergence and current prominence of personalized medicine in the care of cancer patients, in vivo studies on the variants identified in this computational study are highly opportune, in particulary in association with the other risk factors and clinicopathologic parameters of the patients..
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International Medical Journal
Journal ID : IMJ-13-08-2023-1632
Total View : 443
Title : MOLECULAR CHARACTERISATION AND PHYLOGENETIC ANALYSIS OF SHEEPPOXVIRUS RPO30 GENE ISOLATES FROM MOROCCAN SHEEP
Abstract : Sheeppoxvirus (SPPV) and Goatpoxvirus (GTPV) are classified as causal agents of notifiable viral diseases. They belong to the genus Capripoxvirus (CaPV) with the Lumpy skin disease virus (LSDV). Although SPPV and GTPV have host preferences, certain strains may infect sheep and goats. Capripoxvirus (SPPV, GTPV, and LSDV) are antigenically related but genetically distinct and require molecular analysis for differentiation. In this study, the RPO30 gene from six isolates identified in Capripoxvirus outbreaks in different parts of Morocco between 2018 and 2021 were genetically and phylogenetically analysed to describe their genetic relationship. Sequential analysis revealed that the percentage of RPO30 nucleotide identity ranged from 93% to 99%, with CaPVs isolates from other countries. The constructed phylogenetic tree classified the six CaPVs detected as GTPVs. Additional analyses and alignments must be undertaken to facilitate the diagnosis and control of Sheeppox in Morocco..
Full article
International Medical Journal
Journal ID : IMJ-03-08-2023-1630
Total View : 497
Title : Knowledge, Attitude And Practice Of Lassa Fever Prevention Among Undergraduate Students Of University Of Nigeria Enugu Campus
Abstract : Lassa fever (LF), an acute and sometimes fatal viral hemorrhagic disease remains a public health challenge in endemic areas in West Africa including Nigeria. Foodstuff and objects contaminated with multimammate rat, (Mastomys natalensis), droppings or urine is the most common route of disease transmission. Secondary, person-to-person transmission can also occur through exposure to blood or bodily secretion of infected persons (dead or alive). The study was carried out amongst the undergraduate students of university of Nigeria, Enugu Campus to assess the level of knowledge, attitude and practice of Lassa Fever prevention in the student community. A descriptive cross-sectional study was carried out with a sample size of 300 undergraduate students of University of Nigeria, Enugu Campus, (UNEC). A multistage sampling technique was used for sample selection. A simple random sampling method was used to select nine departments from fifteen departments in UNEC and 300 students were then randomly selected from the nine departments. They all met the inclusion criteria. A semi-structured self-administered questionnaire was used for quantitative data collection. Data was analyzed using statistical package for social sciences (SPSS) version 23.0. Data was presented using tables, pie charts and bar charts. The study had a 96% response rate. Results showed that 97% of the respondents have heard of Lassa fever prior to the interview and 62% had knowledge of survival and possible recovery from the disease. The major sources of information amongst our respondents were Radio (53%), television (55.3%) and Blog/Newspaper/Social Media (50.3%). The majority of respondents (70.3%) had a fair attitude towards Lassa fever Virus(LFV) prevention. Although the results showed a fair level of preventive practices amongst University students, the majority of respondents (61%) reportedly declined to participate in a Lassa fever vaccine trial showing that the attitude as well as practice towards Lassa Fever prevention is not corresponding with the level of knowledge demonstrated by the students. Most respondents got their information from television/Newspaper/Social Media, thus supporting the need for continuous campaigns and news items in the public media to sustain the dissemination of information on Lassa fever in order to correct the high knowledge fair attitude mismatch which is necessary for Lassa fever prevention..
Full article
International Medical Journal
Journal ID : IMJ-28-07-2023-1628
Total View : 465
Title : Perception of School Food Environment and Dietary Practice At School Canteen Among Malaysian Secondary School Adolescents
Abstract : Malaysian adolescents are susceptible for an unhealthy and poor dietary practice with an augmented intake of energy-dense food items and reduced intake of nutritious food. Distinctive environmental factors are considered to influence their dietary practice, among which the major contributor is the school food environment where they spent most of their time. This study was to determine the relationship between the public secondary school students’ perception towards their school food environment and their dietary practice involving a sample size of 118 students of Form 1, 2 and 4 from all states of Malaysia. All the data was collected using online platforms through validated and pretested school food environment questionnaire and analysed using IBM SPSS 26. The students had a moderate level of perception (mean= 0.50 ± 0.02) and practice (mean= 2.73 ± 0.04) towards the school food environment. There were significant differences between the students’ perception towards the school food environment and variables namely ethnic groups (Malay, Chinese and Indian) (p-value = 0.001*), father’s education status (p-value = 0.019*), mother’s education background (p-value = 0.038*), and father’s employment status (p-value = 0.014*) respectively. There was a significant, positive, and moderate relationship between students’ perception and practice on healthy diet in school environment (p-value <0.001; r=0.246;). After adjusted for confounding variables, the relationship between students’ perception and practice on healthy diet in school environment remain significant (p-value = 0.007*; r = 0.246). The developments and strategies a healthy school food environment are crucial to enhance their perception and improve their dietary practice in the school canteen..
Full article
International Medical Journal
Journal ID : IMJ-10-07-2023-1627
Total View : 430
Title : Epidemiological, clinical, anatomopathological and molecular profiles of lung cancer in patients at the oncology center of the Cheikh Zaid international university hospital in Rabat.
Abstract : Despite advances in thoracic oncology, the prevalence of primary bronchopulmonary carcinoma (BPC) has been rising for some years. It still represents the leading cause of cancer mortality among males in Morocco and throughout the globe. The aim of this study is to characterize the epidemiological, clinical, prognostic, anatomopathological and molecular features of lung cancer in patients treated at the oncology center of Sheikh Zaid International University Hospital in Rabat. We conducted a retrospective analysis of 158 cases of primary BPC, that were reported at the oncology center of the Sheikh Zaid international university hospital in Rabat. In our cohort, the male preponderance was clearly observed with 140 men (88.6%) versus 18 women (11.4%), with a sex ratio of 7.8 men to one woman. The mean age of the patients at the time of diagnosis was 63.7±10.1 years with extremes of age ranging from 16 to 87 years. The age group between 60 and 69 years represents 48.11% of patients. Smoking was found in 96 patients, i.e. 60.8% of the population studied, including 2 patients who also used cannabis. Alcoholism was found in 32 patients (20.3%). The tobacco-alcohol association was noted in 31 patients, i.e. 19.6%. Diabetes, AHT and tuberculosis were the personal medical history most associated with lung cancer with rates of 15.18%, 14.55% and 5.69% respectively. Chest pain was the dominant symptom in 43 subjects being 27.21%, followed by dyspnea in 18.89% of cases, cough in 17.08% of cases, hemoptysis in 8.86% of cases, weight loss in 6.96% of cases and dysphonia in 3.16% of cases. A significant association (p-value<0.001) was found between the manifestation of chest pain and smoking in men. The tumors were mostly located in the right lung, 42.40% of cases, followed by the left lung accounting with 38.60% of cases. The most frequent histological type was adenocarcinoma (58.86%), followed by squamous cell carcinoma (19.62%) and small cell carcinoma (7.59%). Secondary localizations were objectified, mainly bone (20.88%) and brain (18.89%). EGFR mutation was frequent (23.07% of all patients diagnosed), despite the low number of patients who could perform molecular tests. In the light of the present work, our results are broadly in accordance with the findings of other national and international studies. However, despite its usefulness in the early detection of BPC, molecular diagnostics are still seriously limited in Morocco. As a result, tobacco control measures are critical for lowering the prevalence of this disease..
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