: Individuals with type 2 diabetes mellitus (T2DM) have been found to have higher risks of depression. A better understanding prevalence depression comorbidity may provide key insight for managing multiple comorbidities in primary care and tailored therapeutic interventions. The purpose of this study was to observe the depression symptoms among T2DM outpatients in Yogyakarta and Sleman primary care based on the patient health questionnaire (PHQ-9). A cross-sectional survey was carried out at six primary health centers of Yogyakarta city. During September to December 2019, diabetes mellitus type 2 patients in Prolanis group was recruited. A pre-validated instrument consisted of sociodemograhics and clinical information and A 9-item Patient Health Questionnaire (PHQ 9) scale was used. All data obtained were analyzed descriptively, and Chi-square test was used to determine association between variables and depression symptoms. Most of 475 study participants had minimal depression symptoms score based on PHQ-9 questionnaire. The majority of participants experienced fatigue, insomnia, depressed mood, and loss of appetite symptoms. Association between characteristics participants and severity of depression based on PHQ-9 were found in smoking status, diabetes duration, blood glucose control, comorbidities, and complication showed statistically significant. This study showed that mental health problem especially depression found in type 2 diabetes mellitus outpatient in Yogyakarta and Sleman primary care. Association was found regarding smoking status, diabetes duration, blood glucose control, comorbidities, and complications. Mental health should be a concern to medical practitioners since it linked to poor clinical outcomes and self-monitoring blood glucose.