: Caring for patients with palliative conditions such as cancer, stroke, and chronic renal failure is challenging for nurses. However, experiences of nurses with those palliative conditions have never been well identified especially in Intensive Care Unit. This review aim was to identify and synthesize nurses' experiences in providing palliative care in ICU. This review considers several inclusion criteria: ICU nurses who have directly or ever provided palliative care or end of life care in ICU, articles taken from publications between 2005 and 2019, not dual publications and in English, from ProQuest, EBSCO, and PubMed databases. This review used integrative method and done systematically based on the PRISMA checklist. All articles were assessed using the Critical Appraisal Skill Program (CASP), Qualitative Checklist, and Cohort Study Checklist. There were 11 qualitative and 3 quantitative research designs and most methods used were semi structured interviews. However, the researchers obtained five themes: service integration, caring and supporting, self-development, emotional change, and aspects affecting palliative care. Nurses' experiences are different from one to another when providing palliative care. A good relationship between fellow nurses with other health care professionals and families must be maintained, so that they can work together for providing optimal palliative care services..