International Medical Journal (ISSN:13412051)

Aim and Scope

Aim-

International Medical Journal ISSN: (13412051) is an international open-access journal publishes twelve times each year. The "International Medical Journal" is a peer-reviewed, monthly, online international research journal, which publishes original articles, research articles, review articles with top-level work from all areas of Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody, ENT etc. Researchers in all Medical Science and Pharmacy fields are encouraged to contribute articles based on recent research. Journal publishes research articles and reviews within the whole field of Medical Science and Pharmacy Research, and it will continue to provide information on the latest trends and developments in this ever-expanding subject. International Medical Journal journal covers almost all disciplines of Medical Science and Pharmacy. Researchers and students of M.B.B.S, M.D., D.T.C.D., GYNE., M.S., M.Pharma, And PhD are requested to send their original research articles to International Medical Journal.

Scope-

International Medical Journal ISSN: (13412051) is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:

Anatomy Physiology Biochemistry Pharmacology
Pathology Forensic medicine Microbiology Community Medicine
Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology
Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases
Anaesthesia Cancer research Neurosurgery Orthopedics

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Latest Journals
International Medical Journal
Journal ID : IMJ-30-10-2020-645
Total View : 347

Abstract : Successful recovery of severe COVID-19 with cytokine storm with Plasma Convalescent Therapy or Extracorporeal blood purification, has been with or without methylprednisolone has been reported, but not in diabetes comorbid which in immunocompromised where cortisone is immunosuppressant. So cortisone for anti- inflammation drugs should be not recommended. This study builds the potential benefit and harm of corticosteroid in pandemic COVID-19. Systematic Review with Science Direct search engine using keywords of methylprednisolone and COVID-19 are used. Bayesian analysis and network support this study. Cytokine storm and anti- inflammation/ immunosuppressant and immunocompromised/ comorbid are used. Insulin Resistance Syndrome cases are included, and non is excluded. Pneumonia and DIC as the excess, ventilated patients are also included. Flowchart of 15 references supported the table, one table describe the references. Three Systematic Reviews, 4 case reports, 2 cohorts, 4 reviews, 2 observational with minimal 15,385 subjects. The use of corticosteroid as prevention, treatment, and rehabilitation at mild, medium, severe phases are recorded and analyzed. Cortisone is immunosuppressant stuff that should be used only in a hospitalized patient in critical severe cases in overwhelmed/ hyperinflammatory stage COVID-19 pts. but should be forbidden (not recommended is not enough) in comorbidities. Using cortisone in plant/OTC in this pandemic era should be socialized the danger in the public domain to combat the easy spread.
Full article
International Medical Journal
Journal ID : IMJ-28-10-2020-644
Total View : 346

Abstract :

More evidence confirmed the dopaminergic system involvement in ulcerative colitis (UC) pathogenesis. Genes, coding for D3 dopamine receptor were found in neuromuscular and mucosal layers in colon, as well as on immune cells mostly of primary immune response which indicates D3 receptor as the potential therapeutic target for UC. In present study we checked the hypothesize on the protective role of D3 receptor agonist in experimental models of UC. We used two models of UC: 6% iodoacetamide (IA)-induced UC in Wistar rats (0.1 ml, i.c.); and spontaneously developed colitis in IL-10 KO mice. Rats with IA-induced UC were treated with D3R agonist 7-OH-DPAT (in doses of 0.2 mg/kg and 1 mg/kg, s.c. on the 2nd and 5th days). Autopsy on the 7th day. Clinical, macroscopic and microscopic evaluation of UC were performed. It was indicated that during the normal condition D3R were localized on epithelial, endothelial and enteric neurons of rat’s colon mucosa. During the development of IA-induced UC in rats and UC in IL-10 KO mice, expression of D3R protein markedly decreased and its expression was observed mainly on the surface colonocytes. Treatment with 7-OH-DPAT in dose of 0.2 mg/kg had positive effect on clinical and morphological signs of IA-induced UC in rats. The administration of 7-OH-DPAT altered the mucus composition, also enhanced mast cell and macrophage functional reserve. Activation of D3 dopamine receptor might be the potential molecular target for UC treatment.

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Full article
International Medical Journal
Journal ID : IMJ-28-10-2020-643
Total View : 395

Abstract : COVID-19 is a major Public Health challenge that has affected the world’s economy. Assessment of the knowledge, attitude and practices of Healthcare workers (HCWs) towards COVID-19 can improve or sustain successes being recorded by relevant agencies in the fight against COVID-19. This study sought to determine the levels of knowledge, attitude of HCWs towards COVID-19 among Healthcare workers at the Alex Ekwueme Federal University Teaching Hospital, Abakaliki. A cross-sectional survey was done using semi- structured questionnaires which were pre-tested for clarity and a simple sampling technique. Data collected were analyzed using SPSS version 22. Categorical variables were presented as frequencies and percentages while continuous variables were presented as mean and standard deviation. Out of the 368 respondents, 205 (55.7%) were doctors while 150 (40.8%) were nurses. Others were clerical workers, administrative officers and maintenance workers. The sex distribution showed 181 (49.2%) were males while 187 (50.8%) were females. The 25-34 years’ age group was the modal age group. Knowledge of COVID-19 was generally high amongst respondents recording a correct response to questions about knowledge of COVID- 19 in more than 90% of the case. However, the attitude and practice of COVID-19 infection, prevention and control protocols were generally poor especially for this group of the population who are Health care professionals. Out of the respondents, 41.8% would not stay at home if they had minor COVID-19 like symptoms, only 39.4% would take responsibility to ensure people around them follow good respiratory hygiene. Respondents who would keep social distancing while talking with co-workers, ensure safe disposal of personal protective equipment (PPEs) and safe waste management of PPEs were 56%, 39.9% and 53.8% respectively. This study showed that knowledge of COVID-19 disease prevention protocols is high but attitude/practice of these laid out protocols still desires a lot of effort from HCWs. There is need for training/retraining of HCWs on COVID-19 infection, prevention control strategies to ensure the success being recorded against the disease is sustained while preventing the possibility of a second wave of infection and to be armed with relevant skills to reduce infection amongst co-workers and the public if it does occur.
Full article
International Medical Journal
Journal ID : IMJ-27-10-2020-642
Total View : 452

Abstract : Better follow-up can provide an unrealized opportunity to identify diabetic patients potentially at risk of complications. We evaluated the associations between serum kynurenin/tryptophan ratio and type 2 diabetes. Data were collected from a cohort of 111 patients with type 2 diabetes aged 40 years and older, recruited from January 15, 2018 to May 15, 2018. The K/T ratio was used as a marker of indoleamine 2,3-dioxygenase 1 enzyme activity. The determination of serum tryptophan and kynurenin levels was performed according to an analytical protocol based on liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). 11 non-insulin-treated men and 28 women, mean ages 47.82 ± 9.38 and 49.25 ± 9.77 years, respectively, and 21 insulin-treated men and 51 insulin-treated women, mean ages 66.52 ± 7.30 and 64.63 ± 8.96 years, respectively, were recruited. The K/T ratio was significantly associated with age (r = 0.453, p = 0.004) and duration of diabetes (r = 0.415, p = 0.009) in the non-insulintreated group. It was also significantly associated with age (p < 0.001), blood glucose (r = -0.291, p = 0.013), and HbA1c (r = -0.315, p = 0.007) in insulin-treated patients. The K/T ratio could serve as a novel biomarker for the progression of type 2 diabetes and as a threshold for earlier clinical intervention.
Full article
International Medical Journal
Journal ID : IMJ-25-10-2020-640
Total View : 347

Abstract :

Women with advanced breast cancer (ABC) who are hormone receptor (HR) positive and human epidermal growth factor receptor 2 (HER 2) negative are candidates for first line hormonal therapy including aromatase inhibitors (AI). In the past few years new combination therapies became available as  palbociclib with letrozole; increasing the progression free survival (PFS) [1]. Several studies were conducted to assess the chemo-endocrine combination in ABC among which some assessed the combination of capecitabine with aromatase inhibitors [2].Our study is a prospective phase II trial; we randomly assigned patients with HR positive, Her 2 negative ABC, who didn’t receive previous systemic endocrinal treatment for ABC to receive aromatase inhibitor (AI) or capecitabine (625 mg/m2 bid PO for 14 days; repeated every 21 days)  plus AI administered daily  (CapAI).We carried out an interim analysis to determine the toxicity of the CapAI combination. Toxicity was assessed in both arms. There was no significant difference in the rates of toxicity in both arms regarding haematological toxicity (anaemia, thrombocytopenia and neutropenia), fatigue, nausea, vomiting, diarrhoea, mucositis. But there was significant difference in the hand foot syndrome with the 14.8% in the CapAI arm versus 0 % in the AI only arm, peripheral neuropathy with 25.9 % vs 2.3% and hepatic toxicity 14.8% vs 0 %. Grade 3 toxicity was reported in only 3 patients in our study all in the CapAI arm (fatigue, thrombocytopenia and neutropenia). No permanent discontinuation occurred but 25% dose reduction was done in one patient due to decrease in creatinine clearance.

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