: Mental health literacy is really important among university students since about one-third of university students suffer from a diagnosable mental disorder, and 64% of individuals who dropped out of college did so because of a mental disorder. Although 75% of lifetime disorders have their onset during college years, studies have also shown that college students cannot effectively recognize their mental illness or symptoms. This study aimed to observe the mental health literacy among university students in Yogyakarta, as well as to explore the impact of sociodemographic on the Mental Health Literacy Questionnaire score. A survey-based cross-sectional study, carried out in five universties in Yogyakarta province in January 2020. About 650 health and non-health related field students participated in the study. Mental Health Literacy Questionnaire (MHLq), with previously validated and piloted to non-sample students was delivered. Descriptive analysis and chi-square test were applied to see the association between demographic groups and literacy levels within each sample. Surprisingly, only 18.46% of respondents aware about the mental health status of their friends. The mean of MHLq global score was 113.25, which is relatively low. This study found that gender, level of study, study field, and willingness to join mental health program were significantly affected MHLq global score among students. This study showed that mental health literacy among university students in Yogyakarta was relatively poor. Differences were found regarding gender, level of study, study field, and willingness to join mental health program. More investigations on the mental health literacy of university students Indonesia should be undertaken. Furthermore, intervention such as mental health program to raise and improve awareness about mental health literacy should be embarked on.