International Medical Journal (ISSN:13412051)

Aim and Scope

Aim-

International Medical Journal ISSN: (13412051) is an international open-access journal publishes twelve times each year. The "International Medical Journal" is a peer-reviewed, monthly, online international research journal, which publishes original articles, research articles, review articles with top-level work from all areas of Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody, ENT etc. Researchers in all Medical Science and Pharmacy fields are encouraged to contribute articles based on recent research. Journal publishes research articles and reviews within the whole field of Medical Science and Pharmacy Research, and it will continue to provide information on the latest trends and developments in this ever-expanding subject. International Medical Journal journal covers almost all disciplines of Medical Science and Pharmacy. Researchers and students of M.B.B.S, M.D., D.T.C.D., GYNE., M.S., M.Pharma, And PhD are requested to send their original research articles to International Medical Journal. Azerbaijan Medical Journal Gongcheng Kexue Yu Jishu/Advanced Engineering Science Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Zhenkong Kexue yu Jishu Xuebao/Journal of Vacuum Science and Technology Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering) Zhonghua yi shi za zhi (Beijing, China : 1980) Zhongguo Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of China University of Petroleum (Edition of Natural Science) Teikyo Medical Journal Agricultural Mechanization in Asia, Africa and Latin America Kongzhi yu Juece/Control and Decision Tobacco Science and Technology Technology Reports of Kansai University Asia Life Sciences Open Access Journals Tagliche Praxis Bulletin of National Institute of Health Sciences Journal of the Austrian Society of Agricultural Economics Azerbaijan Medical Journal Gongcheng Kexue Yu Jishu/Advanced Engineering Science Changjiang Liuyu Ziyuan Yu Huanjing/Resources and Environment in the Yangtze Valley Shenyang Jianzhu Daxue Xuebao (Ziran Kexue Ban)/Journal of Shenyang Jianzhu University (Natural Science) General Medicine (ISSN:1311-1817)

Scope-

International Medical Journal ISSN: (13412051) is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Interventional Pulmonology Zhenkong Kexue yu Jishu Xuebao/Journal of Vacuum Science and Technology Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering) Zhonghua yi shi za zhi (Beijing, China : 1980) Zhongguo Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of China University of Petroleum (Edition of Natural Science) Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

Anatomy Physiology Biochemistry Pharmacology
Pathology Forensic medicine Microbiology Community Medicine
Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology
Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases
Anaesthesia Cancer research Neurosurgery Orthopedics

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Latest Journals
International Medical Journal
Journal ID : IMJ-01-03-2023-1600
Total View : 484

Abstract : The endoribonuclease L (RNASEL) is the effector of the 2–5A system, a major enzymatic pathway regulated by interferons, encodes a ribonuclease that plays a significant role in the apoptotic pathway. RNASEL gene has been traditionally associated with Hereditary Prostate Cancer 1 and disease severity. Hereditary genetic alterations in RNASEL affect apoptotic responses, such mutations could possibly contribute to malignancy. In order to investigate the genetic alterations of the RNASEL gene in prostate cancer patients and correlation with clinical and pathological parameters, DNA samples from 100 blood samples from prostate cancer patients were genotyped and confirmed by Sanger sequencing. The frequency and distribution of high frequent mutations were determined and correlated with the patient’s tumor characteristics. Among 100 patients 74 % were carriers to one or more mutations in RNASEL gene. Our results revealed the detection of the RNASEL germline mutations, Arg462Gln variant, a common missense variant causing threefold reduction in enzymatic activity, with a high frequency (58%) in the Moroccan men with prostate cancer. In addition, One of the 100 patients have a nonsense substitution with 1% frequency and for synonymous mutations two substitutions have been detected, c.1263T>C and c.1416T>C with 3% and with 2% frequency rate respectively and frameshift mutations frequency were c.1250_1251insT in 7 patients, c.1256delC in 4% of patients while c.1257delA, c.1351delG and c.1395delG 3 have the same frequency 3%. Five of the most eight frequent missenses detected in our study were predicted to alter the RNASEL protein in all three powerful servers (SIFT, PolyPhen2 and PredictSNP), Those missense variants probably reduce the function of RNASEL as kinase enzyme leading to a defect in protein pathway as tumor suppressor genes. Interestingly, those missense variants were located in the RNASEL protein kinase-like domain. No significant differences between carriers and non-carriers of common mutations detected regarding Pathological Gleason score, PSA concentration, Tumor stage and age at diagnosis, [p > 0.05]. family history data and Clinical significance of mutations detected on prostate tumors progression can be investigated in future analysis. Our findings revealed novel RNASEL alterations in prostate cancer patients and it could be associated with cancer development..
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International Medical Journal
Journal ID : IMJ-25-02-2023-1599
Total View : 439

Abstract : Most studies on the role of oncogenic viruses in the development of prostate carcinoma focus on one particular type of virus without analysing the different interactions that may exist between two or more types of virus. The objective of this study was to examine co-infection with BKPyV, MCPyV, PyV6 and PyV7 viruses in men with PCa (Pca) and their correlations with characteristics clinicopathologic patients. In this study, a total of 80 samples were summer analyzed ; 50 blood samples from of men patients with PCa have summer used to detect BKPyV, MCPyV, PyV6 and PyV7 in blood samples using PCR techniques and 30 control samples, and clinical significance has been analyzed statistically. Of the 50 samples tested, 36% were infected with BKPyV, 24% with PyV6 and 28% with PyV7. A correlation significant to summer observed between the Pathological Gleason score and BMI in co- infected patients. In fact, she can to have an important role in initiation and/ or growth of oncogenic transformation. Our results show that BKPyV PyV6 and PyV7 are cofactors potential for PCa in cases positive for BKPyV, which may lead to the development of new therapies and vaccines preventive..
Full article
International Medical Journal
Journal ID : IMJ-23-02-2023-1598
Total View : 488

Abstract : Cervical cancer (CC) is considered the fourth most common malignancy and the fifth fatal cancer in women, oncogenic Human papillomavirus (HPV) are considered a primary cause of development of cervical cancer. It has also been suggested that viral coexistence may also accelerate the progression of cervical lesions to cervical cancer. This study aims to study the coinfection of Epstein Bar Virus (EBV), Herpesvirus 8 (HHV8) and Hepes simplex type 2 (HSV2) infections in women with cervical cancer with the presence of HPV and their correlations with the clinicopathologic characteristics of patients. In this study, 73 samples that tested positive for Human papillomavirus in previous study were used for the detection of EBV, HHV8 and HSV2 in tumor tissue using Polymerase Chain Reaction techniques, and the clinical relevance was analyzed statistically. The 73 samples (48%) were infected with EBV, (24.65%) infected with HHV8 However, none of the cases were infected with HSV2. The frequency of co-infections was 22% of cases. No significant association was found between co-infection and other clinicopathologic features. Therefore, these results represent arguments in favor of the role of EBV and HHV8 among HPV positive cases, as potential cofactors in cervical carcinogenesis, which could lead us to develop new therapeutics and preventive vaccines..
Full article
International Medical Journal
Journal ID : IMJ-16-02-2023-1596
Total View : 402

Abstract : Cataract formation results from the crystalline lens's loss of optical clarity for any reason. An opacity in the lens or its capsule is known as a cataract. The most prevalent form is age-related, which is brought on by the natural ageing process. The observational cross sectional study carried out, in outpatient department, with total The study involved 497 patients in all. Patients of any gender who are older than 40. People who have cataracts in one or both eyes. 91.15% of the cases in the current study's 994 total eyes had cataractous alterations in one or both of the eyes. The most prevalent type of cataract was nuclear sclerotic (77.37%), then mixed (6.95%), PSC (6.51%), and cortical (2.98%). Grades 3 and higher were more prevalent than the less severe grades when ranked by severity. Nuclear sclerotic and cortical cataract were most common in people between the ages of 51 and 60, respectively. PSC in ages 41 to 50, mature cataract in ages 61 to 70, and multiple cataract in ages 51 to 60. The average age of the eyes with mixed types of cataracts was 58.21 + 9.26 years. All cataract kinds' age differences were statistically different; P value: less than 0.001. Cataract is the most prevalent cause of blindness worldwide, posing substantial visual morbidity. Cataracts are most frequently caused by ageing.12 the mainstay of treatment continues to be surgical control. The epidemiological profile of age-related cataract is still not fully understood, though. This could be as a result of inconsistent standards and the presence of other ocular disorders. In order to better understand the morphology of age-related cataract, the current investigation was carried out..
Full article
International Medical Journal
Journal ID : IMJ-12-02-2023-1595
Total View : 406

Abstract : Endometriosis is defined as the presence of endometrium-like tissue (glands and stroma) outside the lining of uterine cavity, which induces a chronic inflammatory reaction, scar tissue, and adhesions that may distort a woman’s pelvic anatomy [1]. The associated symptoms can impact the patient’s general physical, mental, and social well-being. The present study was undertaken to compare efficacy and side effects of Dienogest and ethinyl estradiol combination with Depot Medroxy Progesterone acetate in the treatment of endometriosis. A single centred, institution based study were carried out from March 2020 to February 2021 at the department of Obstetrics and Gynaecology in NRS Medical College and Hospital after obtaining ethical clearance. Among 72 women 15-45 years of age with pelvic endometriosis were included in this study. Study conducted from March 2020 to February 2021. 72 patients were involved in this study. The data was tabulated in Microsoft Excel software and analysed with SPSS V.24 software. The mean age in group 1 is 30.9 and mean age in group 2 is 29.8 years. In group 1, 63.9% had symptoms for 2 to 5 years and in group 2, 44.4 % had symptoms for 2 to 5 years. In group 1, 33.3% patient showed endometrioma in TVS where in group 2, 22.2% patient showed endometrioma in TVS. Treatment was acceptable to 61%patients in group 1 and treatment was acceptable 16.7% patients in group 2. Treatment was more acceptable in dienogest and ethinyl estradiol group. Ethinyl estradiol and Dienogest is a safe and effective drug for off label use in pain management of pelvic endometriosis. However, further studies in larger population with conventional Combined OCP s as control are needed..
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