: Diabetes Mellitus is a chronic disease that requires a long treatment therapy so that it requires a large amount of money. This study aims to determine the use of antidiabetics and the total cost of therapy for type 2 DM patients in Riau Province, Indonesia.This type of research is observational, descriptive. To determine direct medical costs, data were taken retrospectively from the medical records of outpatient type 2 diabetes mellitus patients at Arifin Achmad Hospital between October 2016 and March 2017.Data were also taken concurrently, namely by conducting interviews to determine direct non- medical costs in patients with type 2 diabetes mellitus. The results obtained were the average total cost per month was Rp. 375,974.54. Direct medical costs include antidiabetic costs of Rp 46,430.53, complication costs of Rp 47,246.90, doctor's examination fees of Rp 25,000, laboratory examination fees of Rp 61,183.84, and diet costs of Rp 46,798.22. Direct non-medical costs include transportation costs of Rp. 24,845.36, while indirect costs are Rp. 122,954.54..