: Many mothers, after childbirth, experience excessive emotions and feel very sad if the baby has complications after childbirth so that the baby must have treated in the NICU room. Postpartum depression is a complication that often arises after delivery, occurring in 6.5-14.5% of postpartum women. Untreated postpartum depression can have long-term adverse effects. This episode of depression can be chronic so that it will affect the quality of life. Depression that occurs in the mother will affect the behavior, emotions, cognitive, and interpersonal children later in life. Postpartum women whose babies have treated at the NICU have believed to have higher levels of depression, anxiety, and symptoms of trauma compared to postpartum women whose babies undergo combined care. Therefore this study aims to screen baby blues for mothers with babies who have treated in the NICU room based on Android Applications. Type of quantitative analytical research with a cross-sectional approach. The sample in this study was 40 people. Performed at Dr. Rasidin Padan in March - July 2019. Screening uses the Android-based Edinburgh Post Natal Depression Scale (EPDS) application. Statistical tests have performed with Chi-Square and binary logistic regression. The results of the study of 40 samples there were 11 people at the age of 20-35 years experienced baby blues with a p-value> 0.05, there were 13 multipara people who experienced baby blues with a p-value <0.05, and there were 11 mothers in infants care at the NICU that is experiencing baby blues.