International Medical Journal (ISSN:13412051)

Aim and Scope

Aim-

International Medical Journal ISSN: (13412051) is an international open-access journal publishes twelve times each year. The "International Medical Journal" is a peer-reviewed, monthly, online international research journal, which publishes original articles, research articles, review articles with top-level work from all areas of Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody, ENT etc. Researchers in all Medical Science and Pharmacy fields are encouraged to contribute articles based on recent research. Journal publishes research articles and reviews within the whole field of Medical Science and Pharmacy Research, and it will continue to provide information on the latest trends and developments in this ever-expanding subject. International Medical Journal journal covers almost all disciplines of Medical Science and Pharmacy. Researchers and students of M.B.B.S, M.D., D.T.C.D., GYNE., M.S., M.Pharma, And PhD are requested to send their original research articles to International Medical Journal.

Scope-

International Medical Journal ISSN: (13412051) is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:

Anatomy Physiology Biochemistry Pharmacology
Pathology Forensic medicine Microbiology Community Medicine
Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology
Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases AMA, Agricultural Mechanization in Asia, Africa and Latin America Teikyo Medical Journal Journal of the Mine Ventilation Society of South Africa
Anaesthesia Cancer research Neurosurgery Orthopedics

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Latest Journals
International Medical Journal
Journal ID : IMJ-05-08-2020-559
Total View : 392

Abstract : Breast reconstruction using autologous flap reconstruction is more feasible in many developing countries. Among these autologous flap procedures is perforator flap. LICAP, TDAP, and SEAP have been used for several years in many cases in our institution. The new approach for volume and defect replacement is breast sharing flap. This reconstruction flap procedure uses the Internal Mammary Artery Perforator (IMAP). We report two cases. The first is the case of A 35-years-old with 6 cm in diameter wound on her lower medial quadrant right breast after right inferomedial quadrant mastectomy. The second is a case of a patient diagnosed breast cancer on her superomedial right breast. In the first case, mammary perforator of true 5th intercostal was used. The flap was generated from the mastopexy contralateral side. IMAP at the level of 5th intercostal space was further dissected and turned over to the acceptor side. The second patient underwent breast sharing flap using IMAP SIC 2nd level. The procedure began with excision of the right breast tumor followed by dissection of the flap from her left breast. Then, the 2nd IMAP was also identified with doppler ultrasound intraoperative. The size of the flap measurement is half of the size of the right breast defect. The postoperative follow-up showed a good result in the volume and shape despite some minor scarring issues. Breast sharing flap is one alternative for reconstruction of the medial breast tumor and can be used for volume replacement and closing the defect.
Full article
International Medical Journal
Journal ID : IMJ-05-08-2020-558
Total View : 402

Abstract : Uric acid is the final oxidation product of purine catabolism. It was being reported by recent literature that serum uric acid levels are associated with insulin resistance and is consider an important risk factor in the development of glucose intolerance, obesity, and metabolic syndrome. It has also been suggested that higher serum uric acid levels might be associated with development of gestational diabetes mellitus, and insulin resistance during pregnancy. Gestational diabetes is defined as glucose intolerance that is not present or recognized prior pregnancy and developed when the placenta produce hormone that interferes with action of insulin; however, it is diagnosed by performing Oral glucose tolerance test. The aim of the study was to find the association between second trimester uric acid level and development of gestational diabetes mellitus. The present study is an observational pilot study conducted at Thumbay Hospital, Ajman, over a period of six months. A total of thirty-three women between 13th-28th weeks of gestational age who attended the Obstetric department were included in this study. Serum uric acid estimation was done in women between 13th-28th weeks of gestation and they were subsequently screened for Gestational diabetes mellitus by Oral Glucose Tolerance Test (OGTT) with 75 gm glucose according to IADPSG criteria. Cut-off value (3.6mg\dL) was used for uric acid levels. 23 pregnant women had normal UA levels out of which 5 (constituting 21.7%) had abnormal FBG. Out of the 10 subjects with UA (>3.6 mg\dL), 2 (constituting 20%) of them where seen to have a high FBG. Moreover, pregnant women with normal UA, 8.7% had high 2-hour Plasma glucose and with UA (>3.6 mg\dL), 9% had high 2-hour plasma glucose. Though there was no statistically significant association found between uric acid and OGTT, a weak positive correlation was observed.
Full article
International Medical Journal
Journal ID : IMJ-03-08-2020-557
Total View : 393

Abstract : Rotavirus, a member of the reovirus circle of relatives, which lead to watery diarrhoea, vomiting and extreme dehydration in young children, rotavirus is commonplace, accounting for 35–60% of acute severe diarrhoea in youngsters below five years of age in international locations without rotavirus vaccine, with the highest attributable percentage in toddlers 1,2. Rotavirus diarrhoea is ubiquitous and, unlike bacterial diarrhoea, is not more usual in settings with terrible water, sanitation and hygiene. Rotavirus has a case-fatality price (CFR) of approximately 2.5% amongst kids in growing nations who gift to health facilities 3. Several rotavirus vaccines are certified and commercially available, all of them have been efficacious in randomized controlled trials in high- and low-profits settings. Two oral rotavirus vaccines are advertised in the world: the monovalent (RV1) Rotarix® and the pentavalent (RV5) RotaTeq®.
Full article
International Medical Journal
Journal ID : IMJ-02-08-2020-556
Total View : 335

Abstract : Inflammasome activation cytokine were associated with bad seminal fluid analysis parameters among infertile men with spinal cord injury suggesting pivotal role of NLRP3 pathway in male infertility. Objective: the present study aims to measurement of NLRP3 inflammasome mRNA expression and their activation cytokines (IL-1ß and IL-18) mRNA expression in semen samples in leukocytospermia and none leukocytospermia infertile men. Methods: semen specimen were collected from 264 infertile men; conventional semen analysis was done according to World Health Organization 2010. Total RNA was extracted from whole semen cells pellet then the relative mRNA expression of the NLRP3, IL-1ß and IL-18 in semen specimens was determined by using qRT- PCR. NLRP3 and caspase-3 proteins in both sperm and leukocytes were detected by Immunoperoxidase staining. Results: there was no significant differences in the amount of NLRP3, IL-1B and IL-18 mRNA expression and NLRP3 protein in the sperm cells between leukocytospermia and non-leukocytospermia infertile men (P>0.05). In contrary there was high significant difference in the NLRP3 protein in leukocytes between these two groups (p≤0.001). While, translated protein of caspase-3 in both sperm and leukocytes was no significantly differed between these two groups (P>0.05). Conclusion: Current study suggests that the NLRP3, IL-1ß were expressed in cellular components of semen sample and their expression unrelated to the state of leukocytospermia, while po-IL- 18 is constitutively expressed in leukocytes, epithelial cells and defective sperm cells and released from these cells into seminal fluid after undergoing to apoptosis and necrosis pathways.
Full article
International Medical Journal
Journal ID : IMJ-25-07-2020-553
Total View : 432

Abstract : The current study was designed to evaluate the effect of EECP therapy with or without trimetazidine(TMZ) in patients with refractory angina via modulating peripheral monocyte expression of Toll like receptor4 (TLR4) and its downstream signaling. A randomized double blind control trial in which 88 stable refractory angina patients allocated into two groups, Enhanced External Counter Pulsation (EECP) group: include 44 patients with stable refractory angina were treated with EECP-Therapy. TMZ-EECP group: include 44 patients with stable refractory angina which gave TMZ 35 mg twice daily in addition to EECP-Therapy. TLR4 levels were assayed in peripheral monocyte by flow cytometry and 8-iso-prostaglandin F2α (8-iso-PGF2 α), interleukin6 (IL6), high mobility group box-1 protein (HMG- BOX) and monocytes chemoattractant protein-1(MCP-1) were also measured beforethe EECP-therapy and before the TMZ giving to patients, and after 35 hours of EECP treatment ( 7 consecutive weeks ).Inhibition in TLR4 expression in peripheral monocyte in both study groups but significantly lower expression level was observed among the TMZ-EECP group (P<0.05). Inflammatory cytokine (HMG Box-1 protein, MCP-1) were remarkably decreased in both study groups but (HMG Box-1 protein, MCP-1 and IL-6) significantly decreasing level was observed among the TMZ-EECP group (P<0.05). Also, the oxidative stress biomarker 8-iso-PGF2α were remarkably decreased in both study groups but significantly decreasing level was observed among the TMZ-EECP group (P<0.05). Timetizidine and EECP therapy decrease the release of HMGB-1 and also decreases the 8-iso-PGF2α serum level. Thus attenuate the TLR4 expression on peripheral monocytes which affect the downstream signaling of TLR4, resulting in decreasing the TLR4 downstream signaling inflammatory markers such as MCP-1 and IL6 levels which yield improvement in the quality of patient’s life by decrease frequency of angina episodes, decreasing the Short-acting nitrate use and change the exercise tolerance and distance.
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