: The purpose of the study was to investigate the structure of cardiovascular comorbid states, their frequency dynamic within the study period, as well as predictors of new-onsets events in end-stage renal disease (ESRD) patients and its incidence rate depending on dialysis modality. The prospective observational cohort study involved 326 ESRD patients, 223 of whom were treated with hemodialysis (HD) and 103 with peritoneal dialysis (PD), between 2012 and 2019. Average duration of prospective observation was 42.2 ± 26.4 months. Оf particular interest were new-onset cardiovascular diseases (CVD). Within the observational timeframe the portion of CVD patients increased by 25.6% and 20.3%, when treated with HD and PD respectively (p=0.2978). The incidence of coronary artery disease was significantly higher in HD compared to PD patients. (23.8% to 8.8%, р = 0.0014; RR 2.7200; 95% СІ: 1.3961 – 5.2992). However, the incidence of heart failure was higher in PD compared to HD patients (20.4% to 5.5%, р < 0.0001; RR 3.7888; 95% СІ: 1.9393 – 7.4023). The independent predictors of new-onset CVD in studied cohort were: diabetes mellitus (HR 2.3116, 95% СІ: 1.5664 – 1.5664), history of MRSA carried (HR 2.1535, 95% СІ: 1.3578 – 3.4156), age (HR 1.0323, 95% СІ: 1.0183 – 1.0465), PD treatment (HR 1.8205, 95% СІ: 1.1259 – 2.9435), serum albumin levels (HR 0.9532, 95% СІ: 0.9122 – 0.9961). The observed results demonstrate an over-time significant increase in frequency of CVDs in those suffering from ESRD. A difference was established in the structure of new-onset CVD events, as well as their predictors, between PD and HD groups.