: There are increasing study reports of rhino-orbital mucormycosis in people with coronavirus disease 2019 (COVID-19) especially from India. Typically, the disease has been found to be linked to COVID-19 infections caused by the newer omicron and delta variants, which have spread rapidly throughout the country. Comorbidities like diabetes and oxygen supplementation or ICU admissions are a sovereign risk factor for both severe COVID-19 and mucormycosis. A retrospective observational study was undertaken at a tertiary health care centre in Amravati, Maharashtra. The present study includes all the patients with invasive mucormycosis of the nasal sinuses who presented to the ENT department, either as an outpatient or following departmental referral and who were either coronavirus positive or had recovered from the coronavirus infection. The patient’s history, imaging findings, comorbidities, management details and follow-up information obtained from patients, were recorded and analyzed. All patients were treated keeping complete surgical debridement as the aim, along with drug administration. We screen seventy-five patients presented with head and neck, respiratory and central nervous systems with a mean (SD) age of 52 (24-83) years. Forty patients (55.33%) were aged between 52 and 83 years, among whom most were males (n=51, 68%) and many of them had medical comorbid illness like leukemia and some of them were underwent chemotherapy (n=6, 8%). The presence of comorbid medical illnesses was associated with a significantly reduced survival rate. The present study shows, the patients who suffered from diabetes represent with significant association with mucormycosis, i.e. p=0.0221. Our study emphasized that the patients who had been partial/completely vaccinated were seen to be having a better immunity to fight against the fungal infection as compared to non-vaccinated patients..