International Medical Journal (ISSN:13412051)

Aim and Scope

Aim-

International Medical Journal ISSN: (13412051) is an international open-access journal publishes twelve times each year. The "International Medical Journal" is a peer-reviewed, monthly, online international research journal, which publishes original articles, research articles, review articles with top-level work from all areas of Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody, ENT etc. Researchers in all Medical Science and Pharmacy fields are encouraged to contribute articles based on recent research. Journal publishes research articles and reviews within the whole field of Medical Science and Pharmacy Research, and it will continue to provide information on the latest trends and developments in this ever-expanding subject. International Medical Journal journal covers almost all disciplines of Medical Science and Pharmacy. Researchers and students of M.B.B.S, M.D., D.T.C.D., GYNE., M.S., M.Pharma, And PhD are requested to send their original research articles to International Medical Journal. Azerbaijan Medical Journal

Scope-

International Medical Journal ISSN: (13412051) is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:

Anatomy Physiology Biochemistry Pharmacology
Pathology Forensic medicine Microbiology Community Medicine
Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology
Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases
Anaesthesia Cancer research Neurosurgery Orthopedics

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Latest Journals
International Medical Journal
Journal ID : IMJ-27-10-2020-642
Total View : 452

Abstract : Better follow-up can provide an unrealized opportunity to identify diabetic patients potentially at risk of complications. We evaluated the associations between serum kynurenin/tryptophan ratio and type 2 diabetes. Data were collected from a cohort of 111 patients with type 2 diabetes aged 40 years and older, recruited from January 15, 2018 to May 15, 2018. The K/T ratio was used as a marker of indoleamine 2,3-dioxygenase 1 enzyme activity. The determination of serum tryptophan and kynurenin levels was performed according to an analytical protocol based on liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). 11 non-insulin-treated men and 28 women, mean ages 47.82 ± 9.38 and 49.25 ± 9.77 years, respectively, and 21 insulin-treated men and 51 insulin-treated women, mean ages 66.52 ± 7.30 and 64.63 ± 8.96 years, respectively, were recruited. The K/T ratio was significantly associated with age (r = 0.453, p = 0.004) and duration of diabetes (r = 0.415, p = 0.009) in the non-insulintreated group. It was also significantly associated with age (p < 0.001), blood glucose (r = -0.291, p = 0.013), and HbA1c (r = -0.315, p = 0.007) in insulin-treated patients. The K/T ratio could serve as a novel biomarker for the progression of type 2 diabetes and as a threshold for earlier clinical intervention.
Full article
International Medical Journal
Journal ID : IMJ-25-10-2020-640
Total View : 346

Abstract :

Women with advanced breast cancer (ABC) who are hormone receptor (HR) positive and human epidermal growth factor receptor 2 (HER 2) negative are candidates for first line hormonal therapy including aromatase inhibitors (AI). In the past few years new combination therapies became available as  palbociclib with letrozole; increasing the progression free survival (PFS) [1]. Several studies were conducted to assess the chemo-endocrine combination in ABC among which some assessed the combination of capecitabine with aromatase inhibitors [2].Our study is a prospective phase II trial; we randomly assigned patients with HR positive, Her 2 negative ABC, who didn’t receive previous systemic endocrinal treatment for ABC to receive aromatase inhibitor (AI) or capecitabine (625 mg/m2 bid PO for 14 days; repeated every 21 days)  plus AI administered daily  (CapAI).We carried out an interim analysis to determine the toxicity of the CapAI combination. Toxicity was assessed in both arms. There was no significant difference in the rates of toxicity in both arms regarding haematological toxicity (anaemia, thrombocytopenia and neutropenia), fatigue, nausea, vomiting, diarrhoea, mucositis. But there was significant difference in the hand foot syndrome with the 14.8% in the CapAI arm versus 0 % in the AI only arm, peripheral neuropathy with 25.9 % vs 2.3% and hepatic toxicity 14.8% vs 0 %. Grade 3 toxicity was reported in only 3 patients in our study all in the CapAI arm (fatigue, thrombocytopenia and neutropenia). No permanent discontinuation occurred but 25% dose reduction was done in one patient due to decrease in creatinine clearance.

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Full article
International Medical Journal
Journal ID : IMJ-25-10-2020-639
Total View : 384

Abstract : To assess the prevalence of academic stress and perceived self-esteem and to identify their associated risk factors among nursing students. A cross-sectional study in which 130 nursing students were selected by convenient sampling. Academic stress and perceived self-esteem were measured by using Academic Stress Scale and Rosenberg’s Self-Esteem Scale. Multiple logistic regression was used to assess the combined effect of various factors associated with academic stress and perceived self-esteem. Overall, 78.46% of nursing students experienced high academic stress and 23.50% had low perceived self-esteem. The highest level of academic stress was more common among second and third year students (AOR 0.35, P 0.04). Academic stress was less common among students who received family support (AOR 5.34, P 0.01) and those having family salary ≥8000 SAR (AOR 0.38, P 0.01). In contrast, perceived self-esteem was low among second and third year students (OR 0.43, P 0.02) and among students who did not received family support (AOR 2.46, P 0.03). It is recommended that academic advising and guidance unit in nursing college to provide psycho-educational interventions concerning academic stress management. These interventions would help make the students to be aware of their level of self-esteem.
Full article
International Medical Journal
Journal ID : IMJ-22-10-2020-637
Total View : 336

Abstract :

За период с 2009 по 2018 год в Шымкенте зарегистрировано 1664 случая суточной смертности больных острым инфарктом миокарда (ОИМ) со снижением с 227 случаев в 2009 году до 63 в 2018 году. Мужчины по сравнению с женщинами более подвержены риску смерти в молодом возрасте (18-44 года), среднем (45-59 лет) и пожилом (60-74 года). На зимний сезон приходится 26,4% смертей, весенний -26,1% и осенний -25,7%, низкая смертность наблюдается летом 21,8%. В холодный период года (ноябрь-март) смертей на 10,0% меньше, чем в теплый период (апрель-октябрь). Однако при пересчете этих показателей на каждые 1000 случаев смерти смертность от ОИМ в холодный период года на 76 случаев выше, чем в теплый. Во все сезоны года показатели смертности повышаются с увеличением возраста больных и преобладанием мужчин в первых трех возрастных группах, особенно в молодой (в 5,7 раза) и средней (в 5 раз). В старческом возрасте смертность от ОИМ заметно снижается и чаще встречается у женщин (в 1,7 раза). Анализ особенностей годовой динамики смертности от ОИМ у взрослого населения г. Шымкента за период с 2009 по 2018 год с использованием индекса сезонности (Си), рассчитанного для каждого месяца и сезона с учетом пола и возраста больных, показал, что высокий риск смертности от ОИМ примерно эквивалентен для трех сезонов года (зима, весна, осень), при некоторой распространенности смертности у мужчин зимой и у женщин весной и осенью. Летом риск развития ОИМ значительно меньше у мужчин и женщин. Существует очень высокий риск увеличения смертности, вызванной ОИМ, во все сезоны года у пациентов в возрасте 45 лет и старше, особенно у пожилых людей. Для всех возрастных групп наибольший риск наблюдается в октябре-декабре. Кроме того, существует высокий риск для молодых людей в июле, средний - в январе, пожилого и старческого возраста в марте.

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Full article
International Medical Journal
Journal ID : IMJ-13-10-2020-634
Total View : 515

Abstract : The purpose of the study was to investigate the structure of cardiovascular comorbid states, their frequency dynamic within the study period, as well as predictors of new-onsets events in end-stage renal disease (ESRD) patients and its incidence rate depending on dialysis modality. The prospective observational cohort study involved 326 ESRD patients, 223 of whom were treated with hemodialysis (HD) and 103 with peritoneal dialysis (PD), between 2012 and 2019. Average duration of prospective observation was 42.2 ± 26.4 months. Оf particular interest were new-onset cardiovascular diseases (CVD). Within the observational timeframe the portion of CVD patients increased by 25.6% and 20.3%, when treated with HD and PD respectively (p=0.2978). The incidence of coronary artery disease was significantly higher in HD compared to PD patients. (23.8% to 8.8%, р = 0.0014; RR 2.7200; 95% СІ: 1.3961 – 5.2992). However, the incidence of heart failure was higher in PD compared to HD patients (20.4% to 5.5%, р < 0.0001; RR 3.7888; 95% СІ: 1.9393 – 7.4023). The independent predictors of new-onset CVD in studied cohort were: diabetes mellitus (HR 2.3116, 95% СІ: 1.5664 – 1.5664), history of MRSA carried (HR 2.1535, 95% СІ: 1.3578 – 3.4156), age (HR 1.0323, 95% СІ: 1.0183 – 1.0465), PD treatment (HR 1.8205, 95% СІ: 1.1259 – 2.9435), serum albumin levels (HR 0.9532, 95% СІ: 0.9122 – 0.9961). The observed results demonstrate an over-time significant increase in frequency of CVDs in those suffering from ESRD. A difference was established in the structure of new-onset CVD events, as well as their predictors, between PD and HD groups.
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