: Among the educational programs, medical education is very important because of itsunique nature and high costs. Students, as the main elements of education, are the best source of informationneeded to determine the quality of education. Therefore, the present study aimed to evaluate theeffectiveness of basic science education on the clinical skills from the viewpoint of the medical interns andexterns at Semnan University of Medical Sciences. In this descriptive cross-sectional study, 102 30-itemquestionnaires were completed by medical students of Semnan University of Medical Sciences during 2017-2018. The questionnaire evaluated four indices of achievement of objectives, content of basic sciencecourses, educational planning and organization, and assessment of professors. The answers were based on a5-point Likert scale varying from undesirable to poor, average, good, and excellent. In this study, 51 femalesand 51 males medical inters and externs participated. From the viewpoint of students, the anatomy(3.42±1.038) and physiology (3.27±1.195) were considered as the most important and influential basicscience courses and physics (1.58±0.895) and biochemistry (1.44±0.752) were evaluated as the leastimportant basic science courses. Evaluation of the effectiveness of the three indices of achievement ofobjectives, educational planning and organization, and assessment of professors from the viewpoint ofstudents showed a mean and standard deviation of less than average. The results showed that clinical aspectsof basic science courses were received less attention, indicating the need to revise current methods of basicsciences in medical education.