Abstract : Despite good advancements for diagnosis and treatment, cancer is still a big threat to our society. 10 million new cases are diagnosed along with 6 million deaths every year. Keeping in view the existence of diverse pattern of cancer occurrence, this study explored the histopathological spectrum of malignancies in tertiary care center in Western Maharashtra. To evaluate the spectrum of malignant lesions in various organs and to study their demographic profile and histopathological features. To evaluate the trend and epidemiological patterns of cancer among patients. This is a combined retrospective and prospective study that included 735 patient specimens obtained either post-surgically or through biopsy. The specimens were evaluated based on site, histopathological features and tumor differentiation. Most of the patients are middle to old age groups. Female were slightly higher in number at 50.07% compared to males at 49.93%. Most common histopathological type of carcinoma included squamous cell carcinoma at 41.22%, followed by adenocarcinoma at 23.54%, infiltrating ductal carcinoma at 19.59%. Most common site of tumors was located at head and neck area at 26.39%, followed by breast carcinoma at 19.6%. Among GIT cancers, esophageal involvement was noted in 5.71%. Bladder cancers accounted for 4.0% whereas kidney cancers accounted for 4.63% of all cancers. In cancers of female genital tract, cervical cancers, ovarian & adnexal tumors, vulval & vaginal tumors accounted for 7.07%, 0.27%, 0.14% respectively. Among cancers of male genital tract, prostate and penis tumors accounted for 10.07%, 1.63% respectively. In our study, majority of tumors were located at head and neck area accounted for 26.39% followed by breast carcinoma at 19.86%. The study showed prevailing epidemiological profile of cancers in Western Maharashtra. Appropriate screening measures can be directed keeping in mind most prevalent cancers and mitigation measures can be taken accordingly..
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Abstract : An incisional hernia is a hernia in the abdomen caused by a prior surgical incision. Wound infection, malnutrition, morbid obesity, chronic cough, prostatism and larger incisions are considered as risk factors for developing incisional hernia. The present study compared the outcome of both laparoscopic and open mesh repair for incisional hernia repair in terms of duration of hospital stay, post-operative pain, time taken to resume normal work and complications. Over a period of 18 months, about 60 patients diagnosed with incisional hernia in a tertiary hospital were enrolled in the study. They were assigned into group A and group B in a randomized manner and group A underwent laparoscopic IPOM/IPOM PLUS and group B underwent open mesh repair. The patients were followed up for a period of 6 months. The difference between two groups in terms of duration of surgery, mean pain score, duration of analgesia, duration of hospital stay, post-operative complications, time taken to resume normal activities were recorded and found to be statistically significant. Laparoscopic approach for incisional hernia has shown better results on comparing with open approach. Laparoscopic incisional hernia repair has low postoperative morbidity with early recovery rate compared to open incisional hernia repair..
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Abstract : Renal cell carcinoma comprehends a heterogeneous group of tumors which account for 2% of all cancers diagnosed. About 80-85% of all renal cell cancers affect males compared with females in the ratio 3:2. The overall incidence increases with life style. In rare instances, RCC affects children and young adults. The present study investigated the serum Vitamin D, calcium, Phosphorous and Magnesium levels in renal cell carcinoma patients. This is a Descriptive Study which includes five groups; Sample size of this study was 60. The study was conducted during the period from January 2017 to August 2018 in the Department of Biochemistry, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, Tamil Nadu. In the present study it was observed that the Vitamin D, calcium, Phosphorous and magnesium levels in serum were significantly decreased (p<0.001) in renal cell carcinoma patients as the disease progresses. Vitamin D deficiency is profound in RCC, with deficiency status increasing as the disease progresses from stage I to stage IV. In the present study we conclude that Vitamin D is a prognostic marker for Renal Cell Carcinoma..
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Abstract : A Supracondylar fracture of humerus is a common paediatric fracture accounting for 50% to 70% of all elbow fractures. The present study is to compare the functional outcome of lateral based configuration versus criss cross pattern of pinning. Prospective study design were constructed with 45 children with Gartland type III supracondylar fractures of humerus, at the Department of Orthopaedics, Meenakshi medical college and research institute, kanchipuram, During the period August 2017 to August 2020.Inclusion criteria were in type III supracondylar fractures of humerus, in age group of 2-12 years, Type I and Type II supracondylar fractures and those treated by open reduction were excluded from study. The children were treated on an emergency basis with closed reduction and percutaneous pinning, under the guidance of C-arm image intensifier. Follow – up was done regularly at 6 weeks, 3 months, 6 months and then once in 6 months. In our series, a total of 45 cases were treated; 28 patients (62%) underwent crossed pinning with medial and lateral pins and 17 patients (38%) underwent lateral pinning. The choice of method of pin fixation was made according to operating surgeon’s personal preference. Pin tract infection with pin loosening occurred in 3 patients in our series (6.6%). The follow-up period for cases ranged from 5 months to 36 months with an average follow-up duration of 19.53 months. In 5 month of follow-up our series was adequate enough to assess fracture union, malalignment, range of motion and recovery from nerve injuries. In our series, the functional outcome following criss cross pinning was excellent in 82% and good in 18% of cases. And cases treated with lateral pinning showed 71% excellent and 29% good results with no poor results. In our study there is no significant difference between the stability provided by criss cross pin fixation and two lateral pin fixation method. But the criss cross pin fixation group show two (7%) cases of iatrogenic ulnar nerve injuries. In the present study we conclude that the lateral pin fixation method for the treatment of Type III supracondylar fracture is safe and reliable..
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Abstract : Ventral hernias are one of the most common challenging problems which the general surgeons confront. The rate of incidence of ventral incisional hernia in the long term after laparotomy has been reported to be 20-25%. Primary suture repair remains one of the oldest techniques. The use of sutures to fix these meshes is associated with complications like infections, seroma, fistulas and chronic pain. Self-gripping mesh has shown promising results in several different kinds of abdominal wall hernias. The aim of our study was to compare outcomes of self-gripping mesh with sutured polypropylene mesh and highlight its promising results. Our study was a comparative interventional study, carried out at SRM medical college hospital between April 2021 to October 2021, in which 80 patients undergoing open ventral hernia repair were selected as per satisfaction of inclusion criteria and divided into two groups: Conventional sutured mesh as Control group and Self- gripping suture-less mesh as Study group. This study was conducted after obtaining the institute human ethics committee approval. The intra- operative time, post-operative pain, post- operative infection and duration of hospital stay were recorded for all these patients and analysed. Based on the study, it was found out that the use of self-gripping mesh was found have less intra -operative time, less post- operative pain and infection and those patients had short hospital stay compared to sutured mesh. Thus self- gripping mesh is worthier as there is no sutures. It is time saving, surgeon friendly and improves patient’s quality of life..
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