International Medical Journal (ISSN:13412051)

Aim and Scope

Aim-

International Medical Journal ISSN: (13412051) is an international open-access journal publishes twelve times each year. The "International Medical Journal" is a peer-reviewed, monthly, online international research journal, which publishes original articles, research articles, review articles with top-level work from all areas of Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody, ENT etc. Researchers in all Medical Science and Pharmacy fields are encouraged to contribute articles based on recent research. Journal publishes research articles and reviews within the whole field of Medical Science and Pharmacy Research, and it will continue to provide information on the latest trends and developments in this ever-expanding subject. International Medical Journal journal covers almost all disciplines of Medical Science and Pharmacy. Researchers and students of M.B.B.S, M.D., D.T.C.D., GYNE., M.S., M.Pharma, And PhD are requested to send their original research articles to International Medical Journal. Changjiang Liuyu Ziyuan Yu Huanjing/Resources and Environment in the Yangtze Valley Shenyang Jianzhu Daxue Xuebao (Ziran Kexue Ban)/Journal of Shenyang Jianzhu University (Natural Science) General Medicine (ISSN:1311-1817) Chinese Journal of Evidence-Based Medicine Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation Lizi Jiaohuan Yu Xifu/Ion Exchange and Adsorption

Scope-

International Medical Journal ISSN: (13412051) is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:

Anatomy Physiology Biochemistry Pharmacology
Pathology Forensic medicine Microbiology Community Medicine
Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology
Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases
Anaesthesia Cancer research Neurosurgery Orthopedics

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Latest Journals
International Medical Journal
Journal ID : IMJ-09-04-2023-1606
Total View : 373
Title : Current Trends in Septic Abortion & Sequelae in a Teaching Hospital of Eastern India
Abstract : Septic abortion is still a challenging problem and a major cause of maternal mortality and morbidity in developing countries. In spite abortion has been legalized in India over three decades, unsafe abortion continues to be a significant contributor of maternal mortality and morbidity. The aim of the present study was to assess the magnitude of septic abortion in a tertiary care referral hospital and study their complications. A single centred, institution based study were carried out from January 2022 to December 2022 at the department of Obstetrics and Gynaecology in Medical College and Hospital, Kolkata after obtaining ethical clearance. Among 597 women <20 to > 40 years of age with abortion were included in this study. The data was tabulated in Microsoft Excel software and analysed with SPSS V.24 software. Incidence of septic abortion was 4.86. Majority of patients were in the age group of 21-30 years 361 (60.47%). spontaneous abortion was 279 (46.73%), criminal abortion was 38 (6.37%) and MTP was 280 (46.90%). Grade I infection was 382 (63.99%), Grade II infection was 212 (35.51%). Conservative treatment given was 85 (14.24%), Surgical (D&E) was 510 (85.43%). Drainage of pus from peritoneal cavity and subtotal hysterectomy was done to 1 (0.17%%) each, ccomplications in case of septic abortion was occurred in 2 (0.34%). Endotoxic Shock for the cause of death was 2 (0.34%) and number of death was 2 (0.34%). Maximum hospital was two to three days was 550 (92.13%). Increasing awareness, making legal abortion services easily available to the masses at cheaper cost, and stringent laws to contain quackery are required to decrease the incidences of illegal and septic abortions, and related maternal morbidity and mortality..
Full article
International Medical Journal
Journal ID : IMJ-05-04-2023-1604
Total View : 371
Title : A Prospective Study of the Occurrence of Avascular Necrosis of the Skeletal System in Post Covid 19 Infected Patients with Corticosteroid Use
Abstract : COVID-19 can have an impact on various biological systems. Avascular necrosis (AVN) as a consequence of "long COVID-19" has not yet been documented in many studies. We predict that the widespread use of life-saving corticosteroids in COVID-19 cases will lead to an increase in AVN cases. We conducted a study documenting the occurrence of AVN in post covid 19 infected patients who had taken corticosteroids during the course of their treatment. The incidence in the current study was 6.5 %. Prednisolone was given to these patients in a mean dose of 760 mg (400–1300 mg) over the course of their treatment, which is less than the mean cumulative dose of around 2000 mg steroid mentioned in the literature for the development of AVN. The average number of days it took for symptoms to appear after the last steroid use was 178 days, or almost six months. According to a literature analysis, developing avascular necrosis on an MRI following steroid treatment in non- covid circumstances takes six to twelve months. The early onset and progression of AVN are accelerated by COVID 19 infection and corticosteroid usage..
Full article
International Medical Journal
Journal ID : IMJ-29-03-2023-1603
Total View : 480
Title : Association of Serum Vitamin D status with gestational diabetes mellitus and other laboratory parameters : A Prospective birth cohort study
Abstract : Diabetes is the most common medical complication of pregnancy. Vitamin D deficiency which was initially considered only to influence bone metabolism, is now known to exert a wide spectrum of extra-skeletal effects. Vitamin D deficiency is closely associated with gestational diabetes mellitus, it also leads to adverse maternal and child outcome. Only few Indian studies are available in this regard. The present study was undertaken to find association of Serum Vitamin D status with gestational diabetes mellitus and other laboratory parameters. A single centred, institution based, prospective birth cohort study was carried out from January 2022 to December 2022 at the department of biochemistry, Jalpaiguri Government Medical College, West Bengal, India after obtaining ethical clearance. 150 patients with GDM and 150 patients with normal blood sugar were involved in this study. The data was tabulated in Microsoft Excel software and analysed with SPSS V.24 software. Mean age of patients with GDM was 23.45±5.361and mean age without GDM was 23.19±5.51. Mean BMI was higher in case (28.16±4.6) group compared to that in control group (24.63±4.1). Mean FBS was higher in case (117.85±6.7) group compared to that in control group (85.55±0.5), mean PPBS was also higher in case (175±1.4) group compared to that in control group (103.11±0.6). The mean serum vitamin D level was lower in case group case (17.43±0.8) compared to that in control group (27.14±1.07). Women with vitamin D deficiency have an increased risk of developing GDM and other complications as compared to those who had normal level of vitamin D..
Full article
International Medical Journal
Journal ID : IMJ-16-03-2023-1601
Total View : 437
Title : The investigation of the deficiency of vitamin D in Moroccan healthy population and the linkage with prostate specific antigen.
Abstract : It was suggested that the risk of prostate cancer is associated with vitamin D deficiency. In this case, one has investigated the hypothesis that the 25 (OH) D statuses affect prostate specific antigen levels. In this regard we studied the association of vitamin D blood status with serum prostate specific antigen (PSA) concentrations. A total of 491 healthy men were diagnosed through the project. We have enlisted 491 Moroccan men of good health. The vitamin D status and serum PSA have been evaluated. The deficiency of Vitamin D (less than 30 ng /ml) was found in 81.7% of the study population. The mean vitamin D level in this population was 22.5 ±9.56 ng /ml. Serum vitamin D and PSA levels, respectively, were significantly negatively associated with age (p < 0.001, 0.005), while no correlation was found linking PSA and vitamin D levels. Our results show that even in regions like ours where there is a lot of sunlight all year round, vitamin D deficiency is widespread. Nevertheless, variations in vitamin D have shown no impact on healthy men's serum PSA levels..
Full article
International Medical Journal
Journal ID : IMJ-01-03-2023-1600
Total View : 484
Title : Molecular alterations of RNASEL protein kinase domain and association with prostate cancer criteria
Abstract : The endoribonuclease L (RNASEL) is the effector of the 2–5A system, a major enzymatic pathway regulated by interferons, encodes a ribonuclease that plays a significant role in the apoptotic pathway. RNASEL gene has been traditionally associated with Hereditary Prostate Cancer 1 and disease severity. Hereditary genetic alterations in RNASEL affect apoptotic responses, such mutations could possibly contribute to malignancy. In order to investigate the genetic alterations of the RNASEL gene in prostate cancer patients and correlation with clinical and pathological parameters, DNA samples from 100 blood samples from prostate cancer patients were genotyped and confirmed by Sanger sequencing. The frequency and distribution of high frequent mutations were determined and correlated with the patient’s tumor characteristics. Among 100 patients 74 % were carriers to one or more mutations in RNASEL gene. Our results revealed the detection of the RNASEL germline mutations, Arg462Gln variant, a common missense variant causing threefold reduction in enzymatic activity, with a high frequency (58%) in the Moroccan men with prostate cancer. In addition, One of the 100 patients have a nonsense substitution with 1% frequency and for synonymous mutations two substitutions have been detected, c.1263T>C and c.1416T>C with 3% and with 2% frequency rate respectively and frameshift mutations frequency were c.1250_1251insT in 7 patients, c.1256delC in 4% of patients while c.1257delA, c.1351delG and c.1395delG 3 have the same frequency 3%. Five of the most eight frequent missenses detected in our study were predicted to alter the RNASEL protein in all three powerful servers (SIFT, PolyPhen2 and PredictSNP), Those missense variants probably reduce the function of RNASEL as kinase enzyme leading to a defect in protein pathway as tumor suppressor genes. Interestingly, those missense variants were located in the RNASEL protein kinase-like domain. No significant differences between carriers and non-carriers of common mutations detected regarding Pathological Gleason score, PSA concentration, Tumor stage and age at diagnosis, [p > 0.05]. family history data and Clinical significance of mutations detected on prostate tumors progression can be investigated in future analysis. Our findings revealed novel RNASEL alterations in prostate cancer patients and it could be associated with cancer development..
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