: Apert syndrome is an autosomal dominant syndrome with a combination of craniosynostosis, syndactyly and midfacial hypoplasia. The incidence is about 15 in 1,000,000 live births. It may present a number of challenges to the anaesthesiologist such as a difficult airway, difficult IV access, airway hyper-reactivity, temperature dysregulation, high blood loss and venous air embolism. Difficult intubation and ventilation may be observed because of abnormal airways. We report a successful endotracheal intubation with use of video laryngoscope to improve visualization of the airway and fibre optic bronchoscope as a stylet for endotracheal tube at the age of 8 months and endotracheal intubation for the same patient for syndactyly release surgery at the age of 5 years..