: We evaluate the diagnostic values of some biomarkers in detecting bacterial coinfection among 40 children with Adenovirus-related severe pneumonia. Interleukin (IL)-6, high-sensitivity C-reactive protein (hs-CRP) tests were conducted. Receiver operating characteristic (ROC) analysis was used to evaluate their diagnostic values. Study findings showed that 9 children had bacterial coinfections (22.5%). The area under the curves was 0.772, 0.696 and 0.575 for PCT, hs-CRP and IL-6, respectively. The optimal cut-off point for PCT was > 2.25 ng/ml (sensitivity 77%, specificity 40%), hs-CRP was > 51.6 mg/dl (sensitivity 50%, specificity 93%), and IL-6 was > 3.36 pg/ml (sensitivity 100%, specificity 31%).