: The present study was to evaluate the role of Galactin-3 in Schizophrenia Disease and the relationship of Oxidative Stress and Inflammation. A total A total of 66 patients, 33 Schizophrenia and 33 normal, who were not diagnosed with acute or chronic infection that have been shown to affect galectin-3 levels, were included in the study. Categorical fluency tests have been carried out using different scales and ELISA method was used to measure galectin-3 level. The findings of the study showed that Galectin-3 level of the Schizophrenia’s group was found higher than the control group (Schizophrenia 7.52 [2.22-16.19], control 7.02 [1.87-20]. However, it was not statistically significant (p = 0.211). According to the results, galectin-3 levels of Schizophrenia’s patients according to SAPS score; the galectin-3 levels of patients in the moderate-severe Schizophrenia (stage 6) group were found to be statistically significantly higher (moderate-severe stage 10.34 [4.83-11.99], mild-moderate stage 8.54 [2.82-15.63], control 6.71 [2.67-32]; p= 0.012). These findings support the existence of galectin-3, which is thought to have an important place in the pathogenesis of Schizophrenia Disease in the literature..