: This systematic review was aimed to establish the safety and efficacy outcomes of statins in diabetes mellitus. Literature review and identification and screening were done according to PRISMA guidelines. Data collected from various articles like PUBMED, WILEY LIBRARY, SCIENCE DIRECT, LANCET, AAPS, SCOPUS, etc. statins have proved the most common safe and efficient medications to treat familial hyperlipidemia besides their minimal side effects. Various risk factors have been linked to statins and new onset diabetes (NOD). The study reveals the remarkable correlation between diabetes type 2, and statins showed significant dose related and duration mild to moderate risk of NOD. Meta-analyses of randomized controlled trials (RCTs) reveals a mild to moderate risk of NOD with statin therapy, while observational studies indicate a more significant association between statins and onset of diabetes. Besides the lipid lowering positive effects of statins in CVD and FH patients, high potency, chronic administration of some individual class statins like atorvastatin, simvastatin progresses the new onset diabetes in specific individuals with underlying risk factors that leads to new onset diabetes. In order to provide conclusiveness between the positive and negative effects of statins, further studies must conduct on large population with different ethnic groups, and hyperglycemic effects of statins can overcome by lifestyle changes, regular exercise, and diet.