: Congenital nasolacrimal duct obstruction (CNLDO) affects up to 20% of all newborns; however, controversies remain regarding the primary treating specialty. The present study aims to evaluate physicians’ knowledge about CNLDO from among all possible specialties that may encounter CNLDO cases. A thorough questionnaire was developed to assess knowledge, attitude, and practice of pediatricians, ophthalmologists, primary care physicians, and general practitioners regarding CNLDO. Ninety-six participants were included in this study with a mean age ± standard deviation of 29.1 ±5.18 years. Marital status significantly affected the mean scores for practice because married doctors had a higher mean score (P=0.045). The practice setting significantly affected only knowledge (p= 0.008) because doctors in university hospitals had a higher mean score (difference, 4.53; confidence [CI], 2.12-6.94). Ophthalmologists had higher knowledge and practice scores than did other specialists. Years of experience also affected the attitude toward CNLDO cases: more experienced doctors had higher scores, regardless of their specialty. Different specialists encounter the common condition CNLDO. Encouraging referrals to ophthalmologists and providing more educational materials to pediatricians is essential because pediatricians are the most common specialists who will encounter such cases.