Abstract : Novel coronavirus become an health emergency by causing severe acute respiratory syndrome and organ failure. Diagnosis of Covid made either by direct antigen detection or by indirect by assessing antibody status against the COVID -19. Aim of this study to assess the seroprevalence conversion after COVID vaccination (Covaxin) in health care workers in North India. Tertiary care hospital based prospective cohort study done in 41 Health Care Workers (HCWs), in duration of 6months. The blood samples of HCWs were taken in between 30 -45 days after Covaxin first vaccination, 30-45 days and 60-65 days after the second dose of Covaxin Vaccination of enrolled HCWs. SARS-CoV-2 IgG antibody against Nucleocapsid Protein (NP) antigen of coronavirus in the serum of HCWs is assessed by chemiluminescence (CLIA) based principal. In 41 Health care workers where number of female was 16 and male was 25, which on follow up after 30 -45 days of first dose Covaxin vaccination shows 29.27% seroconversion, while after in between 30-45 days after second dose of Covaxin vaccination seroconversion rate was 80% and in between 60-65 days after second dose of Covaxin vaccination seroconversion rate was 84.61%. Coronavirus diagnosis by direct antigen detection by reverse transcriptase polymerase chain reaction still gold standard for diagnosis but seroprevalence status assessment can be used to estimate prevalence of COVID-19 as well as efficacy of covid vaccination, beside these seroprevalence play an important role in convalescent plasma therapy..
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Abstract : Vaccination is an effective strategy to reduce the burden of COVID-19, but its success is contingent on vaccine acceptance. In order to avoid the vaccination programme failing, it is necessary to address vaccine-apprehensive persons' worries. The purpose of this study was to determine the level of acceptance rate towards COVID-19 vaccine among Malaysians. An online questionnaire was distributed to 599 respondents via convenience method among Malaysians aged 18 years and above. Out of 599, acceptance rate was 89.2% with majority of the respondents were female (68.4%), aged between 20 to 29 and 30 to 39 years (30.2%), married (57.4%), Muslim (61.1%), Selangor residence (34.3%), bachelor’s holder (63.3%), non-health worker (53.1%), and healthy individuals (59.9%). The most likely reason for refusal of taking COVID-19 vaccine was due to the long-term effect of vaccine (49.6%), gender (p=0.017) and occupation (p=0.038) of the respondents were found to be significantly associated with the likelihood of taking the COVID-19 vaccine. The findings showed that Malaysians have a high level of acceptance for the COVID-19 vaccine. This is a positive outcome is suggesting that the Malaysian government and other relevant organisations should ramp up their campaign and get ready to roll out the COVID-19 mass immunisation programme to Malaysians. Despite the high acceptance rate, it is still vital to address concerns among the vaccine's sceptics by establishing faith in the vaccine's safety and effectiveness through proper vaccine information..
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Abstract : Mild cognitive impairment (MCI) is an early stage of cognitive decline associated with normal aging and dementia. Harmful behavioral activities, mental health issues, and chronic diseases that commonly manifest after retirement may predispose military veterans to MCI. Therefore, a cross-sectional study was conducted among veterans who lived in the urban city of Kuala Lumpur, Malaysia to determine the prevalence of MCI and its associated factors. A total of 406 male veterans with a mean age of 61.5 years old participated in the study. Face-to-face interviews were conducted to obtain information on sociodemographic, behavioral activities, and health-related conditions. All participants underwent cognitive tests using the Bahasa Malaysia version of the Montreal Cognitive Assessment (MoCA-BM). The results showed that the prevalence of MCI was 21.4%. A logistic regression model revealed that low physical activity (adjusted odds ratio (aOR) 10.29), hypertension (aOR 2.22), lower education level (aOR 2.98), subjective memory difficulty (aOR 3.61), and subjective concentration difficulty (aOR 3.95) were associated with a higher likelihood of MCI. In addition, those aged 60 years and above, as well as those in the non-officer group, were associated with a higher risk for MCI with aOR 4.57 and 4.59 respectively. In conclusion, inactivity and hypertension are preventable risk factors MCI. Therefore, military veterans must be encouraged to practice a physically active lifestyle after retirement to maintain a healthy cognitive level..
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Abstract : Guided imagery is now finding widespread scientific and public recognition. Guided imagery is being used to teach psychophysiological relaxation, alleviate anxiety and depression, relieve physical and psychophysiological symptoms, overcome health-endangering habits, resolve conflicts, help patients prepare for surgery and tolerate procedures more comfortably. Quasi-experimental research was conducted to assess the outcome of the guided imagery on pain perception among post caesarean mothers. Non-randomized non-equivalent control group design was adopted for the survey among 60 post caesarean mothers, selected using a non-probability purposive sampling technique. The tools used were Socio-demographic Proforma, Clinical variable and Numerical Pain Intensity Scale. Guided imagery was administered to the experimental group for 20 minutes for three days. The analysis results showed that the mean difference of pain in the experimental group was 2.83 with S.D. 0.65, significantly higher than the mean difference of pain in the control group 1.37 with S.D. 0.51, with a difference in a mean difference of 1.46. The calculated 't' value of 7.89 was more than the table value (2.001) with the degree of freedom 58 at 0.01 level of significance, which was highly significant. Thus, guided imagery effectively reduced the pain perception among post caesarean mothers in the experimental group. The study's findings have implications in nursing practice, education, administration and research..
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Abstract : Non-compaction of left ventricle is an uncommon autosomal dominant disorder and Right ventricle non-compaction is still rarer. It is a rare cardiomyopathy that is believed to arise from an arrest in embryonic endomyocardial development. More recent studies suggest that it can be acquired later on in life sporadically. It may be accompanied by life-threatening complications, which are most commonly heart failure, arrhythmias, and thromboembolic events. We present a case of 40year old man who presented with dyspnea and palpitation since 15 years and was diagnosed after 2D Echocardiography and Cardiac MRI as Bi-ventricular non compaction with Atrial Septal Defect (ASD). To the best of our knowledge, this combination of ASD with biventricular non-compaction has not been reported in literature so far..
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