Abstract : Postoperative complications of cataract surgery might include posterior capsule opacification (PCO, 8-34.3%). The intraocular lens (IOL), the treatment of choice, has the potential to serve as a prophylactic drug reservoir. PubMed and Google Scholar were used to perform this systematic review. We included articles with inclusion criteria were (1) using only MTX-loaded IOL, (2) published in the last 5 years, and (3) available in full text, in English. Methotrexate-poly(lactic-co-glycolic) acid (MTX-PLGA) showed a significant capability of reducing human lens epithelial cell growth (p<0,001). MTX caused a considerable increase in the time required for the posterior capsule to be completely covered with cells (P=0.046). Over the course of 14 days, it demonstrated an initial concentration peak followed by a steady release of MTX. Modification of IOL as drug delivery can be achieved by coating, soaking, or loading with haptics. Methotrexate's biological effect resulted in a long-term inhibition of cellular proliferation without harming endothelial cells. It also has a similar favorable effect on other fibrotic responses as PCO. PLGA encapsulates and stores a substantial amount of the drug, enabling the development of a slow-release device that delivers the drug continuously. Methotrexate-loaded IOL is a potential treatment in the prevention of PCO after cataract surgery..
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Abstract : To estimate the prevalence of myositis and hepatitis in dengue positive patients and their association. This cross sectional study was carried in Acharya Vinoba Bhave Rural Hospital, Sawangi (Meghe), wardha district of central India during the month of June over a period of 3 months. Total 50 serologically diagnosed cases of dengue(NS-1-antigen) fever were included in this study. Participants were divided in 2 groups on bases of Creatinine kinase levels. After detailed history and clinical examination, liver function test, renal function test, Creatinine kinase(CK), creatinine clearance was calculated and urine for myoglobin were sent. Patients were given standard line of management. Out of 50 cases, 25 cases had raised CK levels. And out of those 25 cases, 8 (30%) patients tested positive for myoglobin in urine, (p< 0.05). Presence of myoglobin in urine is an indicator of rhabdomyolysis [1], [2]. Eighty two percent cases had hepatitis with increased SGPT levels, (p<0.05). All patients who had myositis had hepatitis. Twenty-three patients (90%) of 25 patients had raised creatinine levels and decreased creatinine clearance indicating acute kidney injury. All patients with raised CK levels showed hepatitis and evidence of acute kidney injury. Dengue patient should be evaluated for hepatitis and Myositis. Myositis should be predicated early so that acute kidney injury can be prevented. Hepatitis and myositis invariably co-exist and all patient with transaminitis should be evaluated for acute kidney injury and myositis by evaluating CK levels..
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Abstract : A case is presented with a post-traumatic aneurysm spurium of the anterior tibia lartery with peripheral partial embolization and severe progressive fore foot ischemia after initial treatmentof a distal upper ankle fracture three days ago. The procedure consisted of diagnosis, oral anticoagulation, Prostavasin infusions, resection of the aneurysm, and placement of a venous interposition device. After regression of the severe ischemi creaction, the ischemia pain was completely regressed and the patient could be discharged without any symptoms..
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Abstract : The present study aimed to investigate the diagnostic values of noninvasive markers of liver cirrhosis: the concentrations of the enzymes aspartate transaminase (AST), Alanine Aminotransferase (ALT), total bilirubin, direct bilirubin, indirect bilirubin, gamma-glutamyl transferase, Uric Acid, Total Antioxidant Capacity, Total Oxidant Status and Platelet count with hepatic functional markers indices in patients with cirrhosis of liver in varying etiology. Blood samples of patients suffering from severe liver disease 26 were included. The diagnosis was based on a luminescent immune analyzer and biochemical assays using an automatic biochemical analyzer, to analyze the correlation between the hepatic function and fibrosis markers varying etiology in both the cases and controls. The serum levels of biochemical parameters and liver function tests were significantly higher compare to control (P<0.021): the serum levels of oxidative markers were shown significantly lower compared to healthy controls (P<0.020). The analysis between the liver function and three oxidative stress biomarkers of liver disease positively correlated with AST (P<0.004) and gamma-GT (P<0.001), statistically significant oxidative biomarkers, and diagnostic parameters. The concentration of serological parameters indices changed significantly based on the specific liver cirrhosis etiology, diagnostic parametric tests are positively correlations with hepatic disease. Thus, the detection of these biomarkers might improve the prognosis and diagnosis of liver cirrhosis..
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Abstract : Pneumopericardium, pneumomediastinum, and pneumoperitoneum are uncommon complications of severe COVID-19 pneumonia and have been seen in children. A severe case report in adults showed that the presence of pneumomediastinum can suggest a worsening of the condition, necessitating more intensive treatment, and leading to death. We report a rare case of pneumopericardium, pneumomediastinum, and pneumoperitoneum complications in a 14-year-old girl patient with severe COVID-19 pneumonia. Even with proper treatment and medication, the patient’s condition worsened, then on day 14th of hospitalization, unfortunately, the patient died..
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