Abstract : A prospective case-control Study was conducted from September 2019 to August 2021 in the Department of General Surgery, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune. 81 patients were diagnosed as moderate to severe Acute Pancreatitis by CT Severity Index. They were randomly assigned to two groups. Standard institutional protocol was followed for treatment in Group-B, while Group-A was administered subcutaneous injection 100 mcg Octreotide eight hourly for five days. The Octreotide group did not experience any significant pain relief, decrease in TLC/serum amylase/ serum lipase/ CRP or duration of hospital stay. There was no significant difference among both the groups regarding occurrence of complications at 6 and 12 months. Octreotide did not prove to be an effective drug for management of acute pancreatitis and prevention of its complications..
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Abstract : To determine the frequency of depression in patients with Chronic Kidney Diseases (CKD). Observational cross-sectional study. Nephrology outpatient clinics of the Faisal Hospital, Karachi, Pakistan from July to December 2021. A total of 251 CKD patients were included in this study. After taking written informed consent they were requested to fill the Siddiqui –Shah Depression Scale (SSDS), Urdu version questionnaire. Scoring of depression scale was done and participants were labeled as positive for depression according to score. Participants were also categorize as having mild, moderate and severe depression according to Siddiqui –Shah Depression Scale (SSDS). Out of 251 patients there were 127(50.6%) males and 124 (49.4%) females. Frequency of depression in CKD patients was observed in 163(64.9%). In those subjects who have depression 83(33.1%) have mild depression, 56 (22.3%) have moderate depression and 24(9.6%) have severe depression. Depression is frequently found in CKD patients. Most of them have mild depression. Early diagnosis and monitoring the presence of depressive symptoms should be part of the routine care in patients with CKD..
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Abstract : Salivary diagnostics boasts increased accessibility, accuracy and affordability as a diagnostic modality and is safer for patients and healthcare workers compared to pre-existing modalities. Progressive increase in LDH levels are seen to be positively related to the degree of cellular atypia and can be used as a screening tool in assessing the malignant potential of premalignant lesions. Whereas its positive relationship with histological differentiation can be used as a prognostic indicator in malignancies. To study the correlation between salivary Lactate dehydrogenase (LDH) in Head and neck cancer (HNC) with the histopathological grade. Patients who were biopsy proven to have head and neck cancers, were planned for appropriate surgery based on staging and histopathology. Their preoperative salivary LDH and post-operative salivary LDH was measured to look for any change in values to prove a correlation between malignancy and salivary LDH levels and was compared with the histological grade. The grade of differentiation directly corresponds to the salivary LDH levels, with a statistically significant p value=0.0008. Stage wise preoperative salivary LDH shows statistically significance with p-value= 0.013 along with a statistically significant fall post- operatively (p-value=0.018) and at 6 months (p-value=0.046). Poorer the differentiation higher the Salivary LDH levels. There is a possible prognostic role of salivary LDH in head and neck malignancies which needs to be considered as an alternative or adjunct to traditional biopsy..
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Abstract :

One of the most common causes for admission in surgical ward is non healing ulcer. In which diabetes is the most common etiology. In most of the cases, hospital stay of many weeks is required for management of the above. In many cases they ultimately go for amputation. Acute and chronic wounds affect at least 1% of the population. In all sense patients turns to be a burden for society and family. Vacuum assisted closure is a universally accepted method for dressing. It has proved its efficacy for wound dressing. Faster wound healing, shorter hospital stay.Still in our hospital, majority of dressings are conventional our aim is to show the advantage of V.A.C over conventional dressing in our hospital on wound healing. Total 50 patients were enrolled They are divided in to two groups one for conventional dressing group Department of general surgery , Dr D YPatil medical college , hospital and research center , Pimpri, Pune, Dr D Y Patil vidyapeeth, Pune and the other for VAC.Out of 50 patients 25 patients got the VAC dressing done and 25 conventional dressing. Significant reduction in ulcer size was noted in patients with VAC dressing as compared to conventional dressing.VAC therapy is a contemporary technique  for the treatment of wounds. Its introduction has transformed the path of wound care. Based on the findings from the present study and other studies available, VAC assisted wound care results in improved wound healing ( reduction in wound size and formation of healthy granulation) and at a faster rate.

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Abstract : Early detection of COVID 19 is necessary as it has caused increased global mortality along with a variety of manifestations and rapid progression. There are many markers of COVID 19 viral pneumonia but the exist a few predictors of its severity. To observe the prevalence and importance of Eosinopenia and Lymphopenia in predicting severity of COVID-19 cases. The current study involved 81 cases of COVID 19 viral pneumonia of which 40 were classified as mild while 41 were severe requiring ICU care. The relatability between the lymphocyte and eosinophil count of the admitted patients, for severity and outcome of the disease was analysed using statistical analysis software. Among the study participants, 41 were severe cases which required ICU care and 40 were mild cases which required ward care. Out of the 41 severe cases, all 41 patients (100%) were found to have eosinopenia while 28 patients (68.3%) were found to have lymphopenia. Additionally, among the severe cases, 28 patients (68.3%) were found to have both eosinopenia and lymphopenia. A significant association was also found between lymphopenia and Acute Kidney Injury. A significant association was also observed between the presence of eosinopenia, lymphopenia and both simultaneously, and mechanical ventilation. In this study it was found that eosinopenia and lymphopenia can be considered as a marker of severity of COVID 19, thus if admission sample of Complete blood count shows eosinopenia or lymphopenia, such patients must be given vigorous treatment as probability of worsening of clinical condition is higher..
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